期刊
EUROPEAN RADIOLOGY
卷 32, 期 1, 页码 308-318出版社
SPRINGER
DOI: 10.1007/s00330-021-08174-4
关键词
Magnetic resonance imaging; Multiple system atrophy; Parkinson disease
资金
- National Research Foundation of Korea (NRF) - Korea government [2021R1C1C1014413]
- National Research Foundation of Korea [2021R1C1C1014413] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The diagnostic performance of T2*-weighted GRE imaging, SWI, or QSM in differentiating MSA-P from PD was investigated in this study, showing promising results with high sensitivity and specificity. Further large multicenter prospective studies are needed to confirm the findings and explore the potential clinical utility of these imaging techniques.
Objectives To investigate the diagnostic performance of T2*-weighted gradient echo (GRE) imaging, susceptibility-weighted imaging (SWI), or quantitative susceptibility mapping (QSM) in differentiating multiple system atrophy-parkinsonian type (MSA-P) from Parkinson's disease (PD). Methods A systematic literature search through the MEDLINE and EMBASE databases was performed, starting on September 8, 2020, to identify studies evaluating the diagnostic performance of putaminal hypointensity on T2* GRE or SWI and phase shift on QSM in differentiating MSA-P from PD. The pooled sensitivity and specificity were obtained using hierarchical logistic regression modeling and hierarchical summary receiver operating characteristic (HSROC) modeling. The pooled diagnostic yields of T2* GRE, SWI, or QSM among MSA-P patients were calculated using the DerSimonian-Laird random-effects model. Results Twelve original articles with 985 patients were finally included. SWI was performed in seven studies, T2* GRE was performed in three studies, and QSM was performed in two studies. The pooled sensitivity and specificity were 0.65 (95% CI 0.51-0.78) and 0.90 (95% CI 0.83-0.95), respectively. The area under the HSROC curve was 0.87 (95% CI 0.84-0.90). The Higgins I-2 statistic calculations revealed considerable heterogeneity in terms of both sensitivity (I-2 = 72.12%) and specificity (I-2 = 70.38%). The coupled forest plot revealed the threshold effect. For the nine studies in which area under the curve (AUC) was obtainable, the AUC ranged from 0.68 to 0.947, with a median of 0.819. The pooled diagnostic yield of T2* GRE, SWI, or QSM was 66% (95% CI 51-78%). Conclusions Putaminal hypointensity on T2* GRE or SWI and phase shift on QSM might be a promising diagnostic tool in differentiating MSA-P from PD. Further large multicenter prospective study is warranted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据