期刊
EUROPEAN POLYMER JOURNAL
卷 157, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2021.110646
关键词
Injectable hydrogel; Schiff base; Colorectal cancer; 5-Fluorouracil (5-FU); Curcumin
资金
- Royan Institute and Shahid Beheshti University Research Council
A novel hydrogel was developed for the simultaneous administration of two drugs with different hydrophilicity, 5-FU and curcumin. In vitro experiments demonstrated the sustained release of both drugs and enhanced anticancer effects of the combination therapy in colon cancer cells.
5-Fluorouracil (5-FU) in combination with curcumin has been widely investigated for colon carcinoma cancer. The combination therapy using drug delivery systems will hopefully result in improved therapeutic efficacy, targeted delivery and controlled release of therapeutic agents. However, development of single drug carriers for simultaneous administration of both hydrophobic (curcumin) and hydrophilic (5-FU) drugs is still challenging. Here, the micelle-crosslinked hydrogel was synthesized through a reversible Schiff's based reaction between gelatin-hydrazide (Gel-ADH) and self-assembled Pluronic F127-benzaldehyde (PF127-CHO) micelles. The 5-FU was incorporated in hydrogel network and curcumin was incorporated in core of micelles embedded in hydrogel. The in vitro drugs release profile in pH 6.8 and 7.4 exhibited a pH-responsive release pattern and showed more sustain release of 5-FU in combination with curcumin. The exposure of the combined drug formulation in colon cancer cells (HT-29) proved the enhanced anticancer effects. The synergistic inhibitory effects on the cell cycle progression and cell proliferation in HT-29 cells were also confirmed. The developed hydrogel showed the more efficacy for the simultaneous administration of two drugs with different hydrophilicity.
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