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U Gerlach et al.
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CA Whitworth et al.
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B Unsöld et al.
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C Lerche et al.
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BC Schroeder et al.
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MJ Main et al.
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C Lerche et al.
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J Seyfried et al.
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EC Cooper et al.
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M Schwake et al.
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T Kharkovets et al.
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Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels
JK Hadley et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
A constitutively open potassium channel formed by KCNQ1 and KCNE3
BC Schroeder et al.
NATURE (2000)
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels
AD Wickenden et al.
MOLECULAR PHARMACOLOGY (2000)
KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy
MA Rogawski
TRENDS IN NEUROSCIENCES (2000)
Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels
M Pusch et al.
BIOPHYSICAL JOURNAL (2000)
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