期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 906, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2021.174274
关键词
Prostate cancer; TRAMP; Metastasis; Transcription factors; Diosgenin; Protein kinases
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2021R1I1A2060024]
- National Medical Research Council of Singapore [NRNMRPR18101]
- Singapore Ministry of Education [MOE-T2EP30120-0016]
- International Scientific Partnership Program ISPP at King Saud University [0091]
- MOE Tier 1 grant
Research has shown that diosgenin can inhibit the activation of NF-Kappa B/STAT3 in prostate cancer cells and suppress tumor progression in in vivo models. This inhibition is achieved through the suppression of protein kinases and reporter gene activity, leading to reduced expression of tumorigenic gene products.
Prostate cancer (PCa) is a common disease among men especially in the old age. The deregulated activation of oncogenic and pro-survival transcription factors has been linked with tumor progression in PCa patients. The consequence of diosgenin treatment on NF-Kappa B/STAT3 activation in PCa cells as well as transgenic mouse model was determined. We also validated the hypothesis of targeting these transcription factors using in silico proteomics simulation model. Diosgenin abrogated NF-Kappa B/STAT3 activation and this action was caused as a result of suppression of protein kinases and reporter gene activity that led to a substantial reduction in the expression of various tumorigenic gene products. In vivo, diosgenin (2% w/w) when mixed in diet and fed to mice abrogated tumor progression in transgenic mice. Diosgenin was also detected in serum and was well absorbed orally. Overall, our data highlights the promising efficacy of diosgenin in PCa therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据