期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 165, 期 -, 页码 319-336出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2021.05.013
关键词
Image processing; Machine learning; Formulation development; Protein analytics; High-throughput screening; Computer vision
Imaging technology is increasingly utilized in biopharmaceutical formulation research, providing unique information for protein-based biopharmaceutical characterization and development studies. This review offers a comprehensive overview of analytical imaging techniques in the ultraviolet, visible, and infrared sections of the electromagnetic spectrum, outlining their applications in various (bio)physical properties and providing a future perspective on imaging in biopharmaceutical formulation research.
Imaging is increasingly more utilized as analytical technology in biopharmaceutical formulation research, with applications ranging from subvisible particle characterization to thermal stability screening and residual moisture analysis. This review offers a comprehensive overview of analytical imaging for scientists active in biopharmaceutical formulation research and development, where it presents the unique information provided by the ultraviolet (UV), visible (Vis), and infrared (IR) sections in the electromagnetic spectrum. The main body of this review consists of an outline of UV, Vis, and IR imaging techniques for several (bio)physical properties that are commonly determined during protein-based biopharmaceutical formulation characterization and development studies. The review concludes with a future perspective of applied imaging within the field of biopharmaceutical formulation research.
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