4.7 Article

Combinatorial lipid-nanosystem for dermal delivery of 5-fluorouracil and resveratrol against skin cancer: Delineation of improved dermatokinetics and epidermal drug deposition enhancement analysis

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Article Chemistry, Analytical

Development and Validation of a Robust HPLC Method for Simultaneous Estimation of 5-Fluorouracil and Resveratrol and its Application in the Engineered Nanostructured Lipid Carrier

Mohammad Kashif Iqubal et al.

Summary: The developed method for simultaneous estimation of 5-fluorouracil and resveratrol by HPLC was found to be simple, fast, cost-effective, and reproducible. The method was further validated according to the ICH guideline Q2 (R1) and showed precision within acceptable limits. The content of 5-fluorouracil and resveratrol in the formulated NLC was determined to be 99.452% and 96.421%, respectively.

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