Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery

In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.

Automated summary

Arabinoxylans microspheres were shown to protect insulin from degradation in the upper gastrointestinal tract and effectively lower blood glucose levels in diabetic rats, while also improving symptoms and increasing the presence of beneficial bacteria.