Synthesis, Reactivity and Activation Modes of Fluoroalkyl Thiosulfonates and Selenosulfonates

Reagent design is at the cornerstone of modern organofluorine chemistry. The past decades have seen the emergence of diverse families of reagents with the aim of introducing fluoroalkylthio or seleno groups in an efficient and selective way. Among them, highly versatile fluoroalkyl thiosulfonates and selenosulfonates are in the foreground of the recent developments. Their applicability is discussed in detail in this Minireview, with a specific focus on the reactivity and activation modes.

Automated summary

Reagent design plays a crucial role in modern organofluorine chemistry, with a focus on introducing fluoroalkylthio or seleno groups efficiently and selectively. Among them, versatile fluoroalkyl thiosulfonates and selenosulfonates have been at the forefront of recent developments, showing rich chemical reactivity and wide applicability in various studies.