期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2021, 期 32, 页码 4541-4545出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100922
关键词
alpha-Bromocarbonyls; C3-Alkylated imidazopyridines; Photoredox catalysis; Visible light; Zolpidem
The paper introduces a convenient strategy for the synthesis of C3-alkylated imidazopyridines through one pot condensation and alkylation, yielding moderate to high amounts of the desired compounds. This strategy was further developed to enable the short step synthesis of zolpidem, which typically requires a more complex multistep process.
A convenient strategy is presented for the synthesis of C3-alkylated imidazopyridines through one pot condensation and alkylation of alpha-bromocarbonyl compounds with 2-aminopyridines. A series of C3-alkylated imidazopyridines were obtained in moderate to high yields. This strategy was also elaborated to enable the synthesis of zolpidem in short steps, which otherwise require multistep synthesis.
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