4.5 Article

Differential metabolism of choline supplements in adult volunteers

期刊

EUROPEAN JOURNAL OF NUTRITION
卷 61, 期 1, 页码 219-230

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00394-021-02637-6

关键词

Choline; Glycerophosphocholine; Supplementation; Trimethylamine oxide

资金

  1. HiPP-Werk Georg Hipp OHG, a manufacturer of infant formula
  2. Projekt DEAL

向作者/读者索取更多资源

The study compared four different choline supplements and their impact on plasma concentration and kinetics of choline, betaine and TMAO. Results showed that all supplements rapidly increased choline and betaine levels to a similar extent, with egg-PC having the latest peak. Egg-PC may be the best choice for choline supplementation in adults due to potentially lower TMAO production.
Background Adequate intake of choline is essential for growth and homeostasis, but its supply does often not meet requirements. Choline deficiency decreases phosphatidylcholine (PC) and betaine synthesis, resulting in organ pathology, especially of liver, lung, and brain. This is of particular clinical importance in preterm infants and cystic fibrosis patients. We compared four different choline supplements for their impact on plasma concentration and kinetics of choline, betaine as a methyl donor and trimethylamine oxide (TMAO) as a marker of bacterial degradation prior to absorption. Methods Prospective randomized cross-over study (1/2020-4/2020) in six healthy adult men. Participants received a single dose of 550 mg/d choline equivalent in the form of choline chloride, choline bitartrate, alpha-glycerophosphocholine (GPC), and egg-PC in randomized sequence at least 1 week apart. Blood was taken from t = - 0.1-6 h after supplement intake. Choline, betaine, TMAO, and total PC concentrations were analyzed by tandem mass spectrometry. Results are shown as medians and interquartile range. Results There was no difference in the AUC of choline plasma concentrations after intake of the different supplements. Individual plasma kinetics of choline and betaine differed and concentrations peaked latest for PC (at approximate to 3 h). All supplements similarly increased plasma betaine. All water-soluble supplements rapidly increased TMAO, whereas egg-PC did not. Conclusion All supplements tested rapidly increased choline and betaine levels to a similar extent, with egg-PC showing the latest peak. Assuming that TMAO may have undesirable effects, egg-PC might be best suited for choline supplementation in adults. Study registration This study was registered at Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), 17.01.2020, DRKS00020454.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据