4.7 Article

A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis

出版社

SPRINGER
DOI: 10.1007/s00259-021-05401-4

关键词

Tau; PET; [F-18]Flortaucipir; [F-18]RO948; [F-18]MK6240

资金

  1. Lund University
  2. European Research Council
  3. Swedish Research Council
  4. Knut and Alice Wallenberg Foundation
  5. Marianne and Marcus Wallenberg Foundation
  6. Strategic Research Area MultiPark (Multidisciplinary research in Parkinson disease) at Lund University
  7. Swedish Alzheimer Foundation
  8. Swedish Brain Foundation
  9. Parkinson Foundation of Sweden
  10. Parkinson Research Foundation
  11. Skane University Hospital Foundation
  12. Bundy Academy
  13. Swedish federal government

向作者/读者索取更多资源

This study aimed to determine if comparable target regions of interest (ROIs) and cut-offs could be used across different tau PET tracers for the diagnosis of Alzheimer's disease dementia. Comparable diagnostic performance was observed between theory-driven and data-driven ROIs, with the temporal meta-ROI consistently performing well across all tracers with an SUVR threshold of approximately 1.35.
Purpose This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [F-18]flortaucipir, [F-18]RO948, and [F-18]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer's disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods A total of 1755 participants underwent tau PET using either [F-18]flortaucipir (n = 975), [F-18]RO948 (n = 493), or [F-18]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926-0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion The temporal meta-ROI can be used for differential diagnosis of dementia patients with [F-18]flortaucipir, [F-18]RO948, and [F-18]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.

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