4.5 Review

Potential neurobiological links between social isolation and Alzheimer's disease risk

期刊

EUROPEAN JOURNAL OF NEUROSCIENCE
卷 56, 期 9, 页码 5397-5412

出版社

WILEY
DOI: 10.1111/ejn.15373

关键词

Alzheimer's disease; COVID-19; social isolation; synapse

资金

  1. H2020 European Research Council [681181]
  2. UK Dementia Research Institute
  3. Wellcome Trust Translational Neuroscience PhD programme [203801/Z/16/Z]
  4. Alzheimer's Research UK
  5. Medical Research Council
  6. Wellcome Trust [203801/Z/16/Z] Funding Source: Wellcome Trust
  7. MRC [UKDRI-4004] Funding Source: UKRI
  8. European Research Council (ERC) [681181] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

Social isolation is a potentially modifiable lifestyle factor associated with Alzheimer's disease. Research suggests that social isolation may be linked to the development of Alzheimer's disease.
It is estimated that 40% of dementia cases could be prevented by modification of lifestyle factors that associate with disease risk. One of these potentially modifiable lifestyle factors is social isolation. In this review, we discuss what is known about associations between social isolation and Alzheimer's disease, the most common cause of dementia. This is particularly relevant in the time of the COVID-19 pandemic when social isolation has been enforced with potential emerging negative impacts on cognition. While there are neurobiological mechanisms emerging that may account for the observed epidemiological associations between social isolation and Alzheimer's disease, more fundamental research is needed to fully understand the brain changes induced by isolation that may make people vulnerable to disease.

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