期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 54, 期 3, 页码 4906-4919出版社
WILEY
DOI: 10.1111/ejn.15350
关键词
anaesthesia; electrophysiology; fMRI; local field potentials; nociception; pain; regional cerebral blood flow
资金
- Canadian Foundation for Innovation [33731]
- Natural Sciences and Engineering Research council of Canada [06659]
This study compared neurovascular coupling under medetomidine and isoflurane anesthesia during noxious stimulation, showing that medetomidine significantly increased CBF/LFP ratio compared to isoflurane, but this effect was abolished by fasting. Fasting can reduce medetomidine-induced hyperglycemia and improve neurovascular coupling.
Medetomidine and isoflurane are commonly used for general anaesthesia in fMRI studies, but they alter cerebral blood flow (CBF) regulation and neurovascular coupling (NVC). In addition, medetomidine induces hypoinsulinemia and hyperglycaemia, which also alter CBF regulation and NVC. Furthermore, sudden changes in arterial pressure induced by noxious stimulation may affect NVC differently under medetomidine and isoflurane anaesthesia, considering their different effects on vascular functions. The first objective of this study was to compare NVC under medetomidine and isoflurane anaesthesia during noxious stimulation. The second objective was to examine whether fasting may improve NVC by reducing medetomidine-induced hyperglycaemia. In male Wister rats, noxious electrical stimulation was applied to the sciatic nerve in fasted or non-fasted animals. CBF and local field potentials (LFP) were recorded in the somatosensory cortex to assess NVC (CBF/LFP ratio). The CBF/LFP ratio was increased by medetomidine compared with isoflurane (p = 0.004), but this effect was abolished by fasting (p = 0.8). Accordingly, medetomidine produced a threefold increase in blood glucose (p < 0.001), but this effect was also abolished by fasting (p = 0.3). This indicates that isoflurane and medetomidine anaesthesia alter NVC differently, but the undesirable glucose dependent effects of medetomidine on NVC can be prevented by fasting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据