期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 54, 期 7, 页码 6533-6552出版社
WILEY
DOI: 10.1111/ejn.15438
关键词
ageing; bilateral motor control; dual-site transcranial magnetic stimulation; effective connectivity; supplementary motor area-primary motor cortex connectivity
资金
- Australian Government Research Training Program scholarship
- Graduate Women (WA) Inc. Education Trust Barbara Mary Hale Bursary
- Australian Research Council Discovery Early Career Researcher Award [DE190100694]
- Australian Research Council [DE190100694] Funding Source: Australian Research Council
With advancing age, there is a decline in voluntary movement control, possibly due to reduced effective connectivity between the supplementary motor area and primary motor cortex. Older adults show lower SMA-M1 connectivity but better connectivity is associated with better bimanual motor control in this age group.
With advancing age comes a decline in voluntary movement control. Growing evidence suggests that an age-related decline in effective connectivity between the supplementary motor area and primary motor cortex (SMA-M1) might play a role in an age-related decline of bilateral motor control. Dual-site transcranial magnetic stimulation (TMS) can be used to measure SMA-M1 effective connectivity. In the current study, we aimed to (1) replicate previous dual-site TMS research showing reduced SMA-M1 connectivity in older than younger adults and (2) examine whether SMA-M1 connectivity is associated with bilateral motor control in independent samples of younger (n = 30) and older adults (n = 30). SMA-M1 connectivity was measured using dual-site TMS with interstimulus intervals of 6, 7 and 8 ms, and bilateral motor control was measured using the Purdue Pegboard, Four Square Step Test and the Timed Up and Go task. Findings from this study showed that SMA-M1 connectivity was reduced in older than in younger adults, suggesting that the direct excitatory connections between SMA and M1 had reduced efficacy in older than younger adults. Furthermore, greater SMA-M1 connectivity was associated with better bimanual motor control in older adults. Thus, SMA-M1 connectivity in older adults might underpin, in part, the age-related decline in bilateral motor control. These findings contribute to our understanding of age-related declines in motor control and provide a physiological basis for the development of interventions to improve bimanual and bilateral motor control.
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