期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 54, 期 7, 页码 6374-6381出版社
WILEY
DOI: 10.1111/ejn.15447
关键词
brain; fMRI; intranasal-oxytocin; oxytocin; transcriptomics
Neuroimaging studies suggest that intranasal oxytocin may modulate emotional and social processes by altering neural activity patterns. The study found higher OXTR expression in brain regions affected by IN-OXT, indicating a potential mechanism by which it may alter brain functionality through direct activation of central OXTRs.
Neuroimaging studies suggest that intranasal oxytocin (IN-OXT) may modulate emotional and social processes by altering neural activity patterns. The extent of brain penetration after IN-OXT is unclear, and it is currently unknown whether IN-OXT can directly bind central oxytocin receptors (OXTRs). We investigated oxytocin pathway gene expression in regions affected by IN-OXT on task-based fMRI. We found that OXTR is more highly expressed in affected than unaffected subcortical regions; this effect did not vary by task type or sex. Cortical results revealed higher OXTR expression in regions affected by IN-OXT in emotional processing tasks and in male-only data. No significant differences were found in expression of the closely related vasopressin receptors. Our findings suggest that the mechanism by which IN-OXT may alter brain functionality involves direct activation of central OXTRs.
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