相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Synthesis, in vitro and in vivo biological evaluation of novel lappaconitine derivatives as potential anti-inflammatory agents
Lei Pang et al.
ACTA PHARMACEUTICA SINICA B (2020)
Synthesis and evaluation of the HIF-1α inhibitory activity of 3(5)-substituted-4-(quinolin-4-yl)- and 4-(2-phenylpyridin-4-yl)pyrazoles as inhibitors of ALK5
Yan-Wei Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology
Wei Hou et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway
Qing-Kun Shen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Molecular modulators of celastrol as the keystones for its diverse pharmacological activities
Sin Wi Ng et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Synthesis and Biological Evaluation of a Series of Novel Celastrol Derivatives with Amino Acid Chain
Chaohai Pang et al.
CHEMISTRY & BIODIVERSITY (2018)
Molecular targets of celastrol in cancer: Recent trends and advancements
Dharambir Kashyap et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2018)
Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds
Geraldo Celio Brandao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity-activity relationship, antibacterial and urease inhibition activity
Atta Ullah et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Synthesis and Evaluation of the Anticonvulsant Activities of New 5-substitued-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one Derivatives
Guo-Rui Zhang et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2018)
A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Shao-Ru Chen et al.
FRONTIERS IN PHARMACOLOGY (2018)
Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1 alpha and Slug signaling pathways
Jing Ying Wang et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2018)
Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation
Sandra A. C. Figueiredo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds
Sandra A. C. Figueiredo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Novel 2-benzylthio-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides with anticancer activity: Synthesis, QSAR study, and metabolic stability
Jaroslaw Slawinski et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
An overview of quinoline as a privileged scaffold in cancer drug discovery
Robert Musiol
EXPERT OPINION ON DRUG DISCOVERY (2017)
Synthesis and characterisation of celastrol derivatives as potential anticancer agents
Hong-Jian Zhang et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)
Synthesis and evaluation of the anticonvulsant activities of 2,3-dihydrophthalazine-1,4-dione derivatives
Xiang-Jun Liu et al.
MEDICINAL CHEMISTRY RESEARCH (2017)
AlCl3•6H2O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol
Yi Zhu et al.
MOLECULES (2017)
Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity
Wei Hou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Design and synthesis of new triazoles linked to xanthotoxin for potent and highly selective anti-gastric cancer agents
Qing-Kun Shen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling
Ming Yue Li et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2017)
Synthesis of 3-and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities
Wei-Guang Shan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Synthesis of 4-Phenylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidine-5(4H)-one Derivatives and Evaluation of Their Anti-inflammatory Activity
Fu-Jun Pan et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2016)
Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties
Fen Jiang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Synthesis and proapoptotic activity of oleanolic acid derived amides
Lucie Heller et al.
BIOORGANIC CHEMISTRY (2016)
Synthesis and Antimicrobial Evaluation of Aminoguanidine and 3-amino-1,2,4-triazole Derivatives as Potential Antibacterial Agents
Tian-Yi Zhang et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2016)
5Y Design, synthesis, and evaluation of the anticonvulsant and antidepressant activities of pyrido[2,3-d]pyrimidine derivatives
Hong-Jian Zhang et al.
MEDICINAL CHEMISTRY RESEARCH (2016)
Synthesis, antiproliferative and apoptosis-inducing effects of novel asiatic acid derivatives containing alpha-aminophosphonates
Ri-Zhen Huang et al.
RSC ADVANCES (2016)
Impedimetric quantification of the formation process and the chemosensitivity of cancer cell colonies suspended in 3D environment
Kin Fong Lei et al.
BIOSENSORS & BIOELECTRONICS (2015)
Design and synthesis of celastrol derivatives as anticancer agents
Wen-Jian Tang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds
Jana Wiemann et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Anticancer effect of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways
Shweta Shrivastava et al.
EXPERIMENTAL AND MOLECULAR PATHOLOGY (2015)
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Jacques Ferlay et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts
Wei Wei et al.
ONCOTARGET (2014)
Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression
Hyereen Kang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53 polo like kinase 2 (PLK-2) pathway
Ji Hae Kim et al.
CELLULAR SIGNALLING (2013)
Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells
Shuai Huang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Critical Role of Hypoxia Sensor - HIF-1α in VEGF Gene Activation. Implications for Angiogenesis and Tissue Injury Healing
A. Ahluwalia et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
Yan Xia et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells
Wenzong Lu et al.
LIFE SCIENCES (2012)
Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004-2010)
Hyun Seung Ban et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2011)
Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs
Yong Zhou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)
Quinolines and structurally related heterocycles as antimalarials
Kirandeep Kaur et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Targeting hypoxia cell signaling for cancer therapy
Giovanni Melillo
CANCER AND METASTASIS REVIEWS (2007)
Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity
AA Moosavi-Movahedi et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
HIF-1 as a target for drug development
A Giaccia et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
SJ Freedman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)