期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 226, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2021.113865
关键词
Quinoline; Malaria; Cancer; Medicinal chemistry
资金
- Ghent University e Belgium (BOF)
Quinoline, a privileged scaffold in medicinal chemistry, plays a central role in antimalarial and anticancer research, but established quinoline-containing antimalarial drugs are facing widespread resistance. On the other hand, there is a growing interest in quinoline compounds as potential anticancer agents.
Quinoline, a privileged scaffold in medicinal chemistry, has always been associated with a multitude of biological activities. Especially in antimalarial and anticancer research, quinoline played (and still plays) a central role, giving rise to the development of an array of quinoline-containing pharmaceuticals in these therapeutic areas. However, both diseases still affect millions of people every year, pointing to the necessity of new therapies. Quinolines have a long-standing history as antimalarial agents, but established quinoline-containing antimalarial drugs are now facing widespread resistance of the Plasmodium parasite. Nevertheless, as evidenced by a massive number of recent literature contributions, they are still of great value for future developments in this field. On the other hand, the number of currently approved anticancer drugs containing a quinoline scaffold are limited, but a strong increase and interest in quinoline compounds as potential anticancer agents can be seen in the last few years. In this review, a literature overview of recent contributions made by quinoline-containing compounds as potent antimalarial or anticancer agents is provided, covering publications between 2018 and 2020. (C) 2021 Elsevier Masson SAS. All rights reserved.
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