Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties

Cobaltoceniumselenolate is an unusual, highly air-sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero- and homoleptic gold complexes are highly colored, air-stable compounds, which were characterized by H-1/C-13/P-31/Se-77 NMR, IR, UV-Vis, HR-MS and single crystal XRD. Cytotoxicity of these polar, water-soluble complexes was studied against various standard cancer cell lines (A549MDA-MB-231, HT-29) revealing good anticancer activity of all three complexes.

Automated summary

Cobaltoceniumselenolate coordination with Au(I) metal centers results in highly colored, stable compounds with good anticancer activity against various standard cancer cell lines. Characterization of these complexes was done through various analytical techniques such as NMR, IR, UV-Vis, HR-MS and single crystal XRD.