期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 51, 期 9, 页码 2178-2187出版社
WILEY
DOI: 10.1002/eji.202049055
关键词
post-transcriptional regulation; quiescence; proteome; RNA binding proteins; T cell activation
类别
资金
- Oncode Institute
- Dutch Cancer Society [KWF 10132]
- European Research council (ERC) [PRINTERS 817533]
T cells play a central role in the adaptive immune system, protecting us from infections. Activation prompts T cells to change gene expression and produce effector molecules rapidly to combat threats. Dormant T cells regulate protein production to survive and prepare for potential re-infections.
T cells are central players of the adaptive immune system by protecting us from recurring infections and by killing malignant cells. Protective T cell responses rely on the concerted production of effector molecules such as cytolytic mediators, granzymes, and perforins, as well as pro-inflammatory cytokines and chemokines. Once activated, T cells drastically change their gene expression and rapidly respond to insults by producing ample amounts of effector molecules. In the absence of antigen, T cells remain in a quiescent state and survey our body for possible pathogenic insults. Resting T cells are, however, not inert, but continuously regulate their protein production to survive and to be prepared for possible re-infections. Here, we review our current knowledge on the regulation of gene expression in activated and quiescent T cells. We specifically focus on post-transcriptional mechanisms that define the protein output and that allow dormant cells to undergo active signaling and selective translation, keeping them poised for activation. Finally, we discuss which signals drive T cell survival and their preparedness to respond to insults and which mechanisms are involved in these processes.
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