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Evolved to protect, designed to destroy: IL-17-producing γδ T cells in infection, inflammation, and cancer

期刊

EUROPEAN JOURNAL OF IMMUNOLOGY
卷 51, 期 9, 页码 2164-2177

出版社

WILEY
DOI: 10.1002/eji.202049119

关键词

gamma delta T cells; IL-17; Infection; Inflammation; Cancer

资金

  1. Danish Cancer Society (Kraeftens Bekaempelse) [R269-A15747]
  2. Leo Foundation (Leo Fondet) [LF-OC-20-000550]
  3. Novo Nordisk Foundation (Novo Nordisk Fondet) [NNF20OC0065160]

向作者/读者索取更多资源

Gamma delta (γδ) T cells are evolutionarily conserved and have versatile functions in the immune system, playing crucial roles in infection, inflammation, and cancer. Studies in mouse models have provided valuable insights, and increasing evidence suggests their importance in human diseases.
T cells of the gamma delta (gamma delta) lineage are evolutionary conserved from jawless to carti-laginous and bony fish to mammals and represent the swiss army knife of the immune system capable of antigen-dependent or independent responses, memory, antigen presentation, regulation of other lymphocytes, tissue homeostasis, and mucosal barrier maintenance, to list a few. Over the last 10 years, gamma delta T cells that produce the cytokine IL-17 (gamma delta T17) have taken a leading position in our understanding of how our immune system battles infection, inflicts tissue damage during inflammation, and gets rewired by the tumor microenvironment. A lot of what we know about gamma delta T17 cells stems from mouse models, however, increasing evidence implicates these cells in numerous human diseases. Herein, we aim to give an overview of the most common mouse models that have been used to study the role of gamma delta T17 cells in infection, inflammation, and cancer, while at the same time we will evaluate evidence for their importance in humans. We hope and believe that in the next 10 years, means to take advantage of the protective and destructive properties of gamma delta T and in particular gamma delta T17 cells will be part of our standard immunotherapy toolkit.

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