4.2 Review

T cell-mediated autoimmunity in immune thrombocytopenia

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Summary: The aberrant PD-1/PD-L1 pathway is involved in the pathophysiology of ITP, and enhancing PD-1/PD-L1 signaling is a promising therapeutic approach for ITP management. Low-dose decitabine inhibits CTLs cytotoxicity to autologous platelets through the PD-1 pathway in ITP.

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