T cell-mediated autoimmunity in immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. In addition to anti-platelet autoantibodies, CD8(+) T cells have been implicated as a mechanism of platelet destruction. The current evidence for the existence of platelet-specific CD8(+) T cells in ITP is inconclusive. The purpose of this review is to summarize the studies that investigated CD8(+) T cells in ITP and to review the methods that have been used to detect autoreactive CD8(+) T cells in other autoimmune diseases.

Automated summary

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and increased risk of bleeding. While anti-platelet autoantibodies are known to play a role in platelet destruction, the involvement of CD8(+) T cells in ITP remains inconclusive. This review aims to summarize the studies on CD8(+) T cells in ITP and review methods used to detect autoreactive CD8(+) T cells in other autoimmune diseases.