期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 51, 期 12, 页码 -出版社
WILEY
DOI: 10.1111/eci.13640
关键词
diabetic cardiomyopathy; echocardiography; neutrophils; resistin; type 2 diabetes mellitus
资金
- Rete Cardiologica of Italian Ministry of Health [2754291]
- Fondazione Carige
This study investigated the potential association between neutrophil degranulation and patterns of myocardial dysfunction in patients with type 2 diabetes mellitus. Neutrophil degranulation was found to be associated with the restrictive/diastolic dysfunction pattern in these patients.
Objective To investigate the potential association between neutrophil degranulation and patterns of myocardial dysfunction in a cohort of patients with type 2 diabetes mellitus (T2DM). Background Two distinct phenotypes of diabetic cardiomyopathy have been described: a restrictive phenotype with diastolic dysfunction (restrictive/DD) and a dilative phenotype with systolic dysfunction (dilative/SD). However, the underlying determinants of these two patterns are not yet recognized. Methods In this single-centre, observational, cross-sectional study, 492 patients were recruited. Ultrasonographic measurements were performed by two experienced sonographers, blinded to the clinical data of the participants. Serum biomarkers of neutrophil degranulation were measured by enzyme-linked immunosorbent sandwich assay (ELISA). Results After adjustment for confounders, resistin, myeloperoxidase, matrix metalloproteinase 8 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 complex were positively associated with the restrictive/DD pattern compared with the normal pattern. Similarly, MPO was positively associated with the dilative/SD pattern compared with the normal pattern, and resistin was negatively associated with the dilative/SD pattern compared with the restrictive/DD pattern. Conclusions Neutrophil degranulation is associated with the restrictive/DD echocardiographic pattern in patients with T2DM, but not with the normal pattern and dilative/SD patterns. Neutrophils could have a pivotal role in the pathogenesis of myocardial dysfunction, and particularly diastolic dysfunction, in patients with T2DM.
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