4.7 Article

The associations between organophosphate esters and urinary incontinence in the general US population

期刊

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 29, 期 7, 页码 10400-10407

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s11356-021-14153-5

关键词

Organophosphate esters (OPEs); Metabolites; Urinary incontinence; Women; NHANES

资金

  1. National key research and development program of China [SQ2017YFSF090096]
  2. National Natural Science Foundation of China [81702536, 81770756, 81974098, 81974099]
  3. Science and Technology Department of Sichuan Province [2014JY0219, 2017HH0063]

向作者/读者索取更多资源

This study investigated the associations between Organophosphate esters (OPEs) and urinary incontinence, finding a significant correlation between diphenyl phosphate (DPHP) concentrations and mixed urinary incontinence (MUI) in women, but not in men. This suggests a potential gender difference in the relationship between OPE exposure and urinary incontinence.
Organophosphate esters (OPEs) impact health in many ways. Since its relationship with urinary incontinence remains unknown, we aimed to explore their associations in the US general population. We combined the results of urine specimens test and self-reported urinary incontinence conditions from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 among 2666 participants and then conducted linear regression and logistic regression to analyse associations between log2-transformed OPE concentrations and urinary incontinence. We found that 0.92% of men and 15.74% of women complained of mixed urinary incontinence (MUI). The concentrations of diphenyl phosphate (DPHP) were significantly correlated to MUI among women when treated as a continuous variable (adjusted odds ratio (OR) = 1.15; 95% confidence interval (CI), 1.01-1.31; p = 0.0369) and as a categorical variable (adjusted OR = 1.24; 95% CI, 1.03-1.49; p for trend = 0.0245), whereas no positive correlation was found in males. There were no significant associations between the other three OPEs: bis(2-chloroethyl) phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and dibutyl phosphate (DBUP). The association of DPHP with an increased prevalence OR of MUI in women is a public health concern; future prospective studies are needed to explore its potential mechanism.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据