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The impact of coronavirus SARS-CoV-2 (COVID-19) in water: potential risks

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Biodiversity loss and COVID-19 pandemic: The role of bats in the origin and the spreading of the disease

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Summary: The loss of biodiversity in ecosystems has created conditions that led to the COVID-19 pandemic, with factors such as deforestation, habitat changes, unregulated agriculture, and urban growth contributing to increased human-wildlife contact and altered pathogen transmission pathways. Bats, as major hosts for coronaviruses, have adaptations that make them resistant to viral pathogens and can lead to interspecies transmission, playing a significant role in outbreaks such as the current COVID-19 pandemic.

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Uwe Matterne et al.

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Detection and quantification of SARS-CoV-2 RNA in wastewater and treated effluents: Surveillance of COVID-19 epidemic in the United Arab Emirates

Shadi W. Hasan et al.

Summary: Testing SARS-CoV-2 viral loads in wastewater in the United Arab Emirates revealed fluctuating levels in different locations, with government precautionary measures correlating with a decrease in viral loads. None of the 11 wastewater treatment plants' effluents tested positive, indicating the efficiency of treatment technologies in degrading the virus and the safety of treated reused water.

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Quantitative microbial risk assessment (QMRA) of occupational exposure to SARS-CoV-2 in wastewater treatment plants

Ayokunle Christopher Dada et al.

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Fathi Anayah et al.

Summary: The availability of safe drinking water and proper management of wastewater in healthcare facilities are crucial for maintaining safety and protecting human health and the environment. Issues such as rainwater contamination and wastewater disposal impact need to be addressed. Service providers must adhere to health standards, enhance emergency procedures to control the spread of COVID-19, and strengthen collaboration and measures.

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Bashir Adelodun et al.

Summary: Developed nations have made significant improvements in providing quality water resources, but developing countries still lack in this aspect. The COVID-19 pandemic has highlighted the importance of water quality and sanitation, focusing on the pervasive impact of using virus-contaminated water.

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Summary: The latest COVID-19 pandemic has no conventional treatment or vaccine, leading to investigations on the repositioning of existing drugs as potential therapeutic options. Many drugs are currently undergoing clinical trials for efficacy and safety in treating COVID-19.

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The occurrence and control of waterborne viruses in drinking water treatment: A review

Li Chen et al.

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SARS-CoV-2 in wastewater: Challenges for developing countries

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Summary: The COVID-19 pandemic has raised the possibility of fecal-oral transmission, particularly in developing countries where ineffective waste disposal systems and poor sanitation may exacerbate the situation. An inclusive approach at all levels is needed to overcome this challenging situation in these countries.

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Leaving no stone unturned in light of the COVID-19 faecal-oral hypothesis? A water, sanitation and hygiene (WASH) perspective targeting low-income countries

Willis Gwenzi

Summary: The human coronavirus disease COVID-19 is now a global pandemic, with potential faecal-oral transmission being a concern, especially in developing countries. Attention to clean water provision, sanitation, food safety, and hygiene is crucial in combating COVID-19, with further research on faecal-oral transmission direction highlighted.

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Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants

Alexander Crits-Christoph et al.

Summary: Viral genome sequencing, including from wastewater, provides valuable insights into the spread and genetic diversity of SARS-CoV-2 during the COVID-19 pandemic. By analyzing sewage samples, researchers can track specific viral strains and potential introductions of new lineages before they are identified through clinical sequencing.
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Manish Kumar et al.

Summary: This review provides an up-to-date understanding of the impact of SARS-CoV-2 in natural water bodies, focusing on wastewater effluent. Utilizing a quantitative microbial risk assessment framework, it estimates the potential risk of SARS-CoV-2 through various water activities. The review suggests future research needs to address limitations and uncertainties in the risk assessment of SARS-CoV-2 in natural water bodies.

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Summary: The possibility of airborne transmission of SARS-CoV-2 in indoor air environments has been highlighted in the face of the COVID-19 pandemic. Measures such as improving ventilation, maintaining interpersonal distance, and considering the airborne transmission route are crucial for protecting health.

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Warish Ahmed et al.

Summary: Detection of SARS-CoV-2 RNA in wastewater can serve as an early warning system to identify viral hotspots and target localized public health responses. This method provides unique information on asymptomatic and pre-symptomatic cases that may not be captured by clinical testing, showing potential for effective disease surveillance.

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Detection of SARS-CoV-2 RNA in hospital wastewater from a low COVID-19 disease prevalence area

Jose Goncalves et al.

Summary: Previous studies have reported the presence of viral RNA in stool samples from individuals with SARS-CoV and MERS-CoV, suggesting that wastewater from affected communities may contain SARS-CoV-2 RNA. Recent studies have also found SARS-CoV-2 RNA in human feces. Wastewater-based epidemiology is a promising approach to monitor the prevalence of COVID-19 in communities, as demonstrated by the first detection of SARS-CoV-2 RNA in untreated wastewater in Slovenia.

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Plastic residues produced with confirmatory testing for COVID-19: Classification, quantification, fate, and impacts on human health

Jose E. Celis et al.

Summary: The COVID-19 diagnostic tests generate a significant amount of disposable plastic waste, with no clear correlation to a country's population size, GDP, or confirmed cases. The incineration of these plastic residues releases toxic chemicals into the environment, highlighting the need to reduce plastic waste and improve emissions control at incineration plants. In the long term, the development of biodegradable biomedical manufacturing free of toxic chemicals during incineration should be considered.

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Decay of SARS-CoV-2 RNA along the wastewater treatment outfitted with Upflow Anaerobic Sludge Blanket (UASB) system evaluated through two sample concentration techniques

Manish Kumar et al.

Summary: This study presents the decay in genetic material loading of SARS-CoV-2 during wastewater treatment, and evaluates PEG and ultrafiltration as virus concentration methods. The results indicate that the PEG method is more effective in removing inhibitory substances, and the UASB system significantly reduces the genetic loading of SARS-CoV-2.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Quantitative microbial risk assessment of SARS-CoV-2 for workers in wastewater treatment plants

Rafael Newton Zaneti et al.

Summary: The study explores the potential health risks of SARS-CoV-2 in sewage treatment plant workers using a quantitative microbial risk assessment. Results show that estimates of viral RNA in sewage ranged from 4.14 x 10(1) to 5.23 x 10(3) GC.ml(-1), with risks for aggressive and extreme scenarios likely exceeding the tolerable infection risk for SARS-CoV-2.

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An extensive study on the COVID-19 pandemic, an emerging global crisis: Risks, transmission, impacts and mitigation

P. Parthasarathy et al.

Summary: COVID-19, a highly transmissible and pathogenic viral infection, likely originated from bats and is phylogenetically related to SARS-CoV-2. Common clinical symptoms include fever, cough, and fatigue. Effective antiviral medication or vaccine is not yet available, with a death rate of 2.7% and similar pathological characteristics to ARDS.

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ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?

Carolina Scagnolari et al.

Summary: Research shows a strong positive correlation between ACE2 expression and ISG15 in patients with respiratory diseases, but no correlation was found between furin and ISG15. Stimulation experiments with type I and III IFNs revealed that only the truncated ACE2 isoform was significantly upregulated in epithelial cells.

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Manish Kumar et al.

Summary: Wastewater-based Epidemiological (WBE) surveillance is a promising method to assess the pandemic situation in highly populated areas with limited clinical tests. This study in Gandhinagar, India found SARS-CoV-2 RNA in wastewater samples, demonstrating the potential of WBE surveillance to predict COVID-19 case fluctuations.

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Epidemiological surveillance of SARS-CoV-2 by genome quantification in wastewater applied to a city in the northeast of France: Comparison of ultrafiltration- and protein precipitation-based methods

Isabelle Bertrand et al.

Summary: The study developed a method to quantify the SARS-CoV-2 genome in wastewater and used phages as an internal control. Results showed a decrease in SARS-CoV-2 genome concentration in wastewater during lockdown, consistent with a decrease in COVID-19 cases detected in respiratory samples. Such environmental surveillance is crucial for predicting the circulation of the virus in the community.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2021)

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Deposition features of inhaled viral droplets may lead to rapid secondary transmission of COVID-19

Yidan Shang et al.

Summary: A study shows that inhaled viral droplets have different deposition fractions in various locations, with higher fractions in the upper airways than the lower airways. Especially for droplets larger than 10 µm, the oral/laryngeal region has a relatively high deposition fraction, indicating easy transmission through casual talking/coughing.

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Julian Carrillo-Reyes et al.

Summary: This study monitored the presence of SARS-CoV-2 RNA in sewage in Mexico and found that the adsorption method yielded RNA levels two orders of magnitude higher than ultrafiltration. The results suggest that viral RNA becomes concentrated in activated sludge and support the removal of SARS-CoV-2 RNA in wastewater treatment plants.

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Approaches applied to detect SARS-CoV-2 in wastewater and perspectives post-COVID-19

Pabel Cervantes-Aviles et al.

Summary: The detection of SARS-CoV-2 in wastewater is mainly done through viral concentration methods followed by RT-qPCR testing, which shows varying virus recovery rates. It is recommended to use RT-qPCR or RT-ddPCR targeting specific genes to calculate the limit of detection in wastewater samples for more accurate results. Rigorous methodology is needed to identify positive cases in a region based on genomic copies in wastewater.

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The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness

Gerard Duart et al.

Summary: The topology of the single-spanning SARS-CoV-2 envelope (E) protein plays a crucial role in determining the protein's quaternary structure and function. The distribution of charged residues in the E protein sequences from highly pathogenic human coronaviruses stabilizes the Nt(out)-Ct(in) membrane topology. The evolution of the E protein sequence may have resulted in a more robust membrane topology from MERS-CoV to SARS-CoV and SARS-CoV-2.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2021)

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Can shellfish be used to monitor SARS-CoV-2 in the coastal environment?

Marion Desdouits et al.

Summary: The study aimed to assess methods for detecting CoV in the coastal environment, with results showing low yields for PEDV using seawater-based methods, the current norm for norovirus detection applicable to CoV in shellfish, and no contamination of French shores by SARS-CoV-2.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Sabela Balboa et al.

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SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Jurgen Mahlknecht et al.

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SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Correlation of SARS-CoV-2 RNA in wastewater with COVID-19 disease burden in sewersheds

Jennifer Weidhaas et al.

Summary: The study found that SARS-CoV-2 RNA can be detected in wastewater, and highlighted the utility of wastewater epidemiology in assisting public health responses to COVID-19.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Zhonghua Zhou et al.

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