期刊
FEBS LETTERS
卷 590, 期 20, 页码 3510-3516出版社
WILEY
DOI: 10.1002/1873-3468.12440
关键词
alternative splicing; back-splicing; chloroplast; complementary sequences
资金
- National Natural Science Foundation of China (NSFC) [31571306]
- Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund
- Natural Science Foundation of Jiangsu Province of China [BK20141360]
A new regulatory class of small endogenous RNAs called circular RNAs (circRNAs) has been described as miRNA sponges in animals. Using 16 Arabidopsis thaliana RNA-Seq data sets, we identified 803 circRNAs in RNase R-/non-RNase R-treated samples. The results revealed the following features: Canonical and noncanonical splicing can generate circRNAs; chloroplasts are a hotspot for circRNA generation; furthermore, limited complementary sequences exist not only in introns, but also in the sequences flanking splice sites. The latter finding suggests that multiple combinations between complementary sequences may facilitate the formation of the circular structure. Our results contribute to a better understanding of this novel class of plant circRNAs.
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