期刊
FEBS LETTERS
卷 590, 期 22, 页码 4034-4051出版社
WILEY-BLACKWELL
DOI: 10.1002/1873-3468.12327
关键词
Drosophila; hematopoiesis; immune response; parasitism
资金
- CNRS
- University Toulouse III
- Ministere de la Recherche (ANR programme blanc)
- ARC (Association pour la Recherche sur le Cancer)
- CEFIPRA (Centre Franco-Indien pour la Promotion de la Recherche Avancee)
The emergence of hematopoietic progenitors and their differentiation into various highly specialized blood cell types constitute a finely tuned process. Unveiling the genetic cascades that control blood cell progenitor fate and understanding how they are modulated in response to environmental changes are two major challenges in the field of hematopoiesis. In the last 20 years, many studies have established important functional analogies between blood cell development in vertebrates and in the fruit fly, Drosophila melanogaster. Thereby, Drosophila has emerged as a powerful genetic model for studying mechanisms that control hematopoiesis during normal development or in pathological situations. Moreover, recent advances in Drosophila have high-lighted how intricate cell communication networks and microenvironmental cues regulate blood cell homeostasis. They have also revealed the striking plasticity of Drosophila mature blood cells and the presence of different sites of hematopoiesis in the larva. This review provides an overview of Drosophila hematopoiesis during development and summarizes our current knowledge on the molecular processes controlling larval hematopoiesis, both under normal conditions and in response to an immune challenge, such as wasp parasitism.
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