miR-429 is involved in regulation of NF-κBactivity by targeting IKKβ and suppresses oncogenic activity in cervical cancer cells

Dysregulation of microRNAs ( miRNAs) can contribute to tumorigenesis in cancers. In this study, we found that miR-429 was downregulated in cervical cancer ( CC) tissues and suppressed cell viability and proliferation while promoting apoptosis in CC cells. IKK beta was a novel target gene of miR-429 and ectopic expression of IKKb abrogated the phenotypes induced by miR-429. When IKKb was downregulated by miR-429, nuclear factor kappa B ( NF-kappa B) pathway activation, interleukin-6(IL- 6), and interferon-beta (IFN-beta) production were decreased in CC cells. These findings indicate that miR-429 is involved in regulation of the NF-kappa B pathway by targeting IKK beta and functions as a tumor suppressor in cervical carcinogenesis.