期刊
FEBS LETTERS
卷 591, 期 1, 页码 118-128出版社
WILEY
DOI: 10.1002/1873-3468.12502
关键词
cervical cancer; IKK beta; miR-429; NF-kappa B
资金
- National Natural Science Foundation of China [91029714, 31270818, 81572790]
- Natural Science Foundation of Tianjin [12JCZDJC25100]
Dysregulation of microRNAs ( miRNAs) can contribute to tumorigenesis in cancers. In this study, we found that miR-429 was downregulated in cervical cancer ( CC) tissues and suppressed cell viability and proliferation while promoting apoptosis in CC cells. IKK beta was a novel target gene of miR-429 and ectopic expression of IKKb abrogated the phenotypes induced by miR-429. When IKKb was downregulated by miR-429, nuclear factor kappa B ( NF-kappa B) pathway activation, interleukin-6(IL- 6), and interferon-beta (IFN-beta) production were decreased in CC cells. These findings indicate that miR-429 is involved in regulation of the NF-kappa B pathway by targeting IKK beta and functions as a tumor suppressor in cervical carcinogenesis.
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