期刊
ENVIRONMENTAL POLLUTION
卷 278, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2021.116842
关键词
Polycyclic aromatic hydrocarbon; Weighted quantile sum; Liver function; Inflammation; Blood lipids
资金
- National Science Foundation of China [81900281, 91839102, 91943301]
- Key Specialty Construction Project of Pudong Health and Family Planning Commission of Shanghai [PWZzk2017-10]
- National Key Research and Development Program [2018YFC1004203, 2019YFA0802701]
The study found that mixed PAH exposure was associated with elevated ALT levels in females, with 2-fluorene being the main contributing factor. Urinary 2-fluorene was positively correlated with elevated ALT levels, and it was also found to increase white blood cell, triglyceride, and total cholesterol levels.
Associations between polycyclic aromatic hydrocarbons (PAHs) and respiratory diseases have been widely studied, but the effects of PAH on liver toxicity in adolescents are unclear. Here, 3194 adolescents with NHANES data from 2003 to 2016 were selected. PAH exposure was assessed by measuring PAH metabolites in urine. The outcome variables were the levels of alanine aminotransferase (ALT), aspartate amino transferase (AST) and gamma-glutamyl transpeptidase (GGT). The association between PAH exposure and liver function was evaluated by the weighted quantile sum (WQS) and logistic regression, and the associations between PAHs and inflammation and blood lipids were evaluated by linear regression. Covariates were adjusted for age, ethnicity, BMI, physical activity, family income, cotinine, and urinary creatinine. The results showed that for females, mixed PAH exposure was related to an increased ALT level (OR = 2.33, 95% CI 1.15, 4.72), and 2-fluorene contributed the most (38.6%). Urinary 2-fluorene was positively associated with an elevated ALT level (OR = 2.19 95% 1.12, 4.27, p for trend = 0.004). Mechanistically, 2-fluorene can cause a 3.56% increase in the white blood cell count, a 6.99% increase in the triglyceride level, and 1.70% increase in the total cholesterol level. PAHs may have toxic effects, possibly mediated by inflammation and blood lipids, on the adolescent female liver. Additional confirmatory studies are needed. ? 2021 Elsevier Ltd. All rights reserved.
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