期刊
ENVIRONMENTAL POLLUTION
卷 278, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2021.116752
关键词
Air pollution; Stillbirth; Epidemiological study; Meta-analysis; Systematic review
资金
- National Key R&D Program of China [2018YFA0606200]
- National Natural Science Foundation of China [42075178, 81602819]
- Fundamental Research Funds for the Central Universities [19ykpy88]
- Guangdong Provincial Natural Science Foundation Team Project [2018B030312005]
- Zhongyuan Science and Technology Innovation Leadership Program [214200510016]
The study indicates that maternal exposure to PM2.5, CO, and O3 are associated with an increased risk of stillbirth, while PM10, SO2, and NO2 show no significant impact. Further well-designed cohort studies and investigations into potential biological mechanisms are needed to elaborate on the suggestive associations.
Stillbirth has a great impact on contemporary and future generations. Increasing evidence show that ambient air pollution exposure is associated with stillbirth. However, previous studies showed inconsistent findings. To clarify the effect of maternal air pollution exposure on stillbirth, we searched for studies examining the associations between air pollutants, including particulate matter (diameter <= 2.5 mu m [PM2.5] and <= 10 mu m [PM10]) and gaseous pollutants (sulfur dioxide [SO2], nitrogen dioxide [NO2], carbon monoxide [CO] and ozone [O-3]), and stillbirth published in PubMed, Web of Science, Embase and Cochrane Library until December 11, 2020. The pooled effect estimates and 95% confidence intervals (CI) were calculated, and the heterogeneity was evaluated using Cochran's Q test and I-2 statistic. Publication bias was assessed using funnel plots and Egger's tests. Of 7546 records, 15 eligible studies were included in this review. Results of long-term exposure showed that maternal third trimester PM2.5 and CO exposure (per 10 mu g/m(3) increment) increased the odds of stillbirth, with estimated odds ratios (ORs) of 1.094 (95% CI: 1.008-1.180) and 1.0009 (95% CI: 1.0001-1.0017), respectively. Entire pregnancy exposure to PM2.5 was also associated with stillbirth (OR: 1.103, 95% CI: 1.074-1.131). A 10 mu g/m(3) increment in O3 in the first trimester was associated with stillbirth, and the estimated OR was 1.028 (95% CI: 1.001-1.055). Short-term exposure (on lag day 4) to O-3 was also associated with stillbirth (OR: 1.002, 95% CI: 1.001-1.004). PM10, SO2 and NO2 exposure had no significant effects on the incidence of stillbirth. Additional well-designed cohort studies and investigations regarding potential biological mechanisms are warranted to elaborate the suggestive association that may help improve intergenerational inequality. (c) 2021 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据