期刊
FEBS LETTERS
卷 590, 期 8, 页码 1163-1173出版社
WILEY-BLACKWELL
DOI: 10.1002/1873-3468.12154
关键词
actin polymerization inhibitor; bioprobe; chemical biology; cytoskeleton; seco-clavilactone B
资金
- [24310167]
- [26750373]
Phenotype-based chemical screening is an attractive strategy for the identification of bioactive compounds. We searched for a compound that induces cellular morphological change and identified a novel compound that we named seco-clavilactone B (Seco-CB). Treatment with Seco-CB decreased the ratio of filament actin (F-actin) to globular actin (G-actin). An in vitro actin polymerization assay revealed that Seco-CB inhibited actin polymerization directly. Further analysis demonstrated that the inhibitory effect of Seco-CB on actin polymerization was associated with Seco-CB binding to either Thr5 or Cys285 of actin. These data indicate that Seco-CB is a novel actin polymerization inhibitor.
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