期刊
ENVIRONMENT INTERNATIONAL
卷 153, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2021.106525
关键词
Chromium; Ribosome; rDNA; Nucleolus; Copy number
资金
- NIEHS [R01ES027981, P30ES000002]
- Harvard Global Institute (HGI) award
Exposure to hexavalent chromium induces instability in the rDNA of human cells, leading to rapid amplification and contraction of the array. Environmental exposure and drinking habits, but not age, influence the natural variation in rDNA copy number in human populations exposed to Cr (VI).
Hexavalent Chromium [Cr (VI)] is an established toxicant, carcinogen, and a significant source of public health concern. The multicopy ribosomal DNA (rDNA) array is mechanistically linked to aging and cancer, is the most evolutionarily conserved segment of the human genome, and gives origin to nucleolus, a nuclear organelle where ribosomes are assembled. Here we show that exposure to Cr (VI) induces instability in the rDNA, triggering cycles of rapid, specific, and transient amplification and contraction of the array in human cells. The dynamic of environmentally responsive rDNA copy number (CN) amplification and contraction occurs at doses to which millions of individuals are regularly exposed. Finally, analyses of human populations occupationally exposed to Cr (VI) indicate that environmental exposure history and drinking habits but not age shape extensive naturally occurring rDNA copy number variation. Our observations identify a novel pathway of response to hexavalent chromium exposure and raise the prospect that a suite of environmental determinants of rDNA copy number remain to be discovered.
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