期刊
ENDOCRINE REVIEWS
卷 43, 期 1, 页码 19-34出版社
ENDOCRINE SOC
DOI: 10.1210/endrev/bnab022
关键词
Obesity surgery; weight loss; eating behavior; gut hormones; energy expenditure
资金
- Rosetrees Trust [M825]
- British Society for Neuroendocrinology
- JP Moulton Charitable Foundation
- National Institute of Health Research
- Imperial College Healthcare Charity
- Novo Nordisk
- MRC [MR/R022259/1, MR/J0003042/1, MR/L020149/1, MR/L02036X/1]
- BBSRC
- NIHR
- Integrative Mammalian Biology Capacity Building Award
- EuroCHIP grant [FP7-HEALTH-2009-241592]
- NIHR Biomedical Research Centre Funding Scheme
- Wellcome Trust [212625/Z/18/Z]
- Diabetes UK Project grant [BDA16/0005485]
- Innovative Medicines Initiative 2 Joint Undertaking [115881]
- European Union's Horizon 2020 research and innovation program
- EFPIA
- Irish Research Council [IRCLA/2017/234]
- Health Research Board [USIRL-2016-2]
- Medical Research Council [MR/L02036X/1] Funding Source: researchfish
- MRC [MR/R022259/1, MR/L020149/1] Funding Source: UKRI
- Irish Research Council (IRC) [IRCLA/2017/234] Funding Source: Irish Research Council (IRC)
- Health Research Board (HRB) [USIRL-2016-2] Funding Source: Health Research Board (HRB)
Obesity surgery is the most effective treatment for obesity and its complications, and mechanisms related to weight loss include central appetite control, release of gut peptides, change in microbiota, and bile acids. However, the exact combination and timing of signals remain largely unknown.
Obesity surgery remains the most effective treatment for obesity and its complications. Weight loss was initially attributed to decreased energy absorption from the gut but has since been linked to reduced appetitive behavior and potentially increased energy expenditure. Implicated mechanisms associating rearrangement of the gastrointestinal tract with these metabolic outcomes include central appetite control, release of gut peptides, change in microbiota, and bile acids. However, the exact combination and timing of signals remain largely unknown. In this review, we survey recent research investigating these mechanisms, and seek to provide insights on unanswered questions over how weight loss is achieved following bariatric surgery which may eventually lead to safer, nonsurgical weight-loss interventions or combinations of medications with surgery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据