期刊
ENDOCRINE REVIEWS
卷 42, 期 5, 页码 528-583出版社
ENDOCRINE SOC
DOI: 10.1210/endrev/bnab021
关键词
genetics; imaging; immunology; insulin; islet amyloid polypeptide
资金
- United States Department of Veterans Affairs [I01BX001060]
- VA Puget Sound Health Care System (Seattle, WA), Seattle Institute for Biomedical and Clinical Research (Seattle, WA)
- National Institutes of Health [P30 DK017047]
- Canadian Institutes of Health Research [PJT-153156]
- Juvenile Diabetes Research Foundation [1-INO-2019-794-S-B]
- Juvenile Diabetes Research Foundation Postdoctoral Fellowship [3-PDF-2017-373-A-N]
- University of Washington
- Dutch Diabetes Foundation
- European Union Marie Sklodowska-Curie Fellowship
This review discusses the potential utility of biomarkers related to islet β-cells in diabetes, including genetic markers, circulating molecules, immune cell phenotyping, and imaging approaches. It also considers how these biomarkers complement the traditional measurements of β-cell secretory function.
The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet beta cell. Impairments in propeptide processing and secretory function, along with the loss of these vital cells, is demonstrable not only in those in whom the diagnosis is established but typically also in individuals who are at increased risk of developing the disease. Biomarkers are used to inform on the state of a biological process, pathological condition, or response to an intervention and are increasingly being used for predicting, diagnosing, and prognosticating disease. They are also proving to be of use in the different forms of diabetes in both research and clinical settings. This review focuses on the beta cell, addressing the potential utility of genetic markers, circulating molecules, immune cell phenotyping, and imaging approaches as biomarkers of cellular function and loss of this critical cell. Further, we consider how these biomarkers complement the more long-established, dynamic, and often complex measurements of beta-cell secretory function that themselves could be considered biomarkers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据