相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review
Genetics & Heredity
Karsten Suhre et al.
Summary: The integration of genetics and plasma proteomics provides insights into human disease, revealing connections between genetic and non-genetic risk factors with clinical outcomes. Proteomic analysis offers valuable information on disease mechanisms, clinical biomarkers, and therapeutic opportunities, highlighting the potential for discovering novel drug targets and translational biomarkers through association studies.
NATURE REVIEWS GENETICS
(2021)
Article
Biochemical Research Methods
Nuno Bandeira et al.
Summary: The increase in clinical proteomics studies has raised concerns about managing and disseminating potentially sensitive human proteomics data. Balancing data privacy with efficient use and reuse of research efforts through sharing clinical proteomics data will require development efforts at different levels including bioinformatics infrastructure, policymaking, and mechanisms of oversight.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Joel Selkrig et al.
Summary: Understanding how SARS-CoV-2 manipulates host cellular machinery on a system-wide scale is crucial for developing host-directed therapies. In this study, temporal alterations in host protein thermostability during infection were observed, converging on cellular processes such as cell cycle regulation. Pharmacological inhibition of host proteins with altered thermal stability or abundance could suppress SARS-CoV-2 replication.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Philipp E. Geyer et al.
Summary: The study utilized proteomics to analyze serum proteomes of COVID-19 patients and controls, finding significant changes in 26% of proteins in COVID-19 patients, including proteins related to the immune system and coagulation mechanisms. The research also revealed correlations between SARS-CoV-2 antibodies and immunoglobulin regions through mass spectrometry-based proteomics, showing potential pathophysiological relevance.
EMBO MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jake Lever et al.
Summary: CoronaCentral resource utilizes machine learning to process research literature related to SARS-CoV-2, providing researchers with categorized analysis of content, pace, and focus. The resource, updated daily, covers topics such as therapeutics, disease forecasting, and long COVID.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Vadim Demichev et al.
Summary: This study investigates the time-dependent progression of COIVD-19 inpatients by measuring diagnostic parameters and plasma proteomes, revealing an initial spike in inflammatory response followed by tissue repair and immunomodulation. Prognostic marker signatures for treatment strategies were identified and machine learning models based on proteome show transferability to independent cohorts.
Article
Biochemistry & Molecular Biology
Bo Shen et al.
Article
Multidisciplinary Sciences
David E. Gordon et al.
Article
Biochemistry & Molecular Biology
Mehdi Bouhaddou et al.
Article
Biochemistry & Molecular Biology
Christoph B. Messner et al.
Article
Immunology
Ting Shu et al.