ATP and cancer immunosurveillance

While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic metabolism of all the cellular compartments that form the tumor microenvironment (TME), extracellular ATP operates as a potent signal transducer. The net effects of purinergic signaling on the biology of the TME depend not only on the specific receptors and cell types involved, but also on the activation status of cis- and trans-regulatory circuitries. As an additional layer of complexity, extracellular ATP is rapidly catabolized by ectonucleotidases, culminating in the accumulation of metabolites that mediate distinct biological effects. Here, we discuss the molecular and cellular mechanisms through which ATP and its degradation products influence cancer immunosurveillance, with a focus on therapeutically targetable circuitries.

Automated summary

In the TME, intracellular ATP plays a critical role in bioenergetic metabolism, while extracellular ATP functions as a signal transducer, affecting biology dependent on receptor types, cell types, and regulatory circuitry activation status. Additionally, extracellular ATP is rapidly degraded, leading to the accumulation of metabolites with distinct biological effects.