期刊
EMBO JOURNAL
卷 40, 期 15, 页码 -出版社
WILEY
DOI: 10.15252/embj.2020105740
关键词
co-transcriptional processes; RNA polymerase II; transcription speed
资金
- Ligue Nationale Contre le Cancer (equipe labellisee) [EL-190350]
- Fondation Toulouse Cancer Sante [DRUGSPEED 2018-2]
- Fondation de France
- Ligue Contre le Cancer [31]
The speed of RNA polymerase II plays a critical role in determining transcriptome composition, which can adapt cells to changing environments. Analyzing the dynamics of RNA Pol II speed is essential for understanding physiological regulation and its impact on the development of multicellular organisms. There is also evidence suggesting that deregulation of RNA Pol II speed may contribute to disease progression.
RNA polymerase II (RNA Pol II) speed or elongation rate, i.e., the number of nucleotides synthesized per unit of time, is a major determinant of transcriptome composition. It controls co-transcriptional processes such as splicing, polyadenylation, and transcription termination, thus regulating the production of alternative splice variants, circular RNAs, alternatively polyadenylated transcripts, or read-through transcripts. RNA Pol II speed itself is regulated in response to intra- and extra-cellular stimuli and can in turn affect the transcriptome composition in response to these stimuli. Evidence points to a potentially important role of transcriptome composition modification through RNA Pol II speed regulation for adaptation of cells to a changing environment, thus pointing to a function of RNA Pol II speed regulation in cellular physiology. Analyzing RNA Pol II speed dynamics may therefore be central to fully understand the regulation of physiological processes, such as the development of multicellular organisms. Recent findings also raise the possibility that RNA Pol II speed deregulation can be detrimental and participate in disease progression. Here, we review initial and current approaches to measure RNA Pol II speed, as well as providing an overview of the factors controlling speed and the co-transcriptional processes which are affected. Finally, we discuss the role of RNA Pol II speed regulation in cell physiology.
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