期刊
FASEB JOURNAL
卷 30, 期 8, 页码 2662-2672出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201600435RR
关键词
regulatory mechanisms; multiple sclerosis; stroke; neurovascular unit; inflammation
资金
- Multiple Sclerosis Society of Great Britain
- Biotechnology and Biological Sciences Research Council [BB/K009184/1]
- Multiple Sclerosis Society of Northern Ireland
- BBSRC [BB/K009184/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K009184/1] Funding Source: researchfish
Brain endothelial cells constitute the major cellular element of the highly specialized blood-brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS. Therefore, compromised function of brain endothelial cells has serious consequences for BBB integrity. This has been associated with early events in the pathogenesis of several disorders that affect the CNS, such as multiple sclerosis, HIV-associated neurologic disorder, and stroke. Recent studies demonstrate that brain endothelial microRNAs play critical roles in the regulation of BBB function under normal and neuro-inflammatory conditions. This review will focus on emerging evidence that indicates that brain endothelial microRNAs regulate barrier function and orchestrate various phases of the neuro-inflammatory response, including endothelial activation in response to cytokines as well as restoration of inflamed endothelium into a quiescent state. In particular, we discuss novel micro RNA regulatory mechanisms and their contribution to cellular interactions at the neurovascular unit that influence the overall function of the BBB in health and during neuroinflammation. -Lopez-Ramirez, M.A., Reijerkerk, A., de Vries, H.E., Romero, I. A. Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据