Electrochemiluminescence Single-cell Analysis on Nanostructured Interface

Due to the heterogeneity of single cells, the development of single-cell analysis methods is conducive to the research of cellular mechanisms, clinical diagnosis, and treatment. Electrochemiluminescence (ECL) has the advantage of being controllable in time and space. Compared with spectroscopy, ECL does not require a light source, thus avoiding the interference of scattered light and luminescent impurities. Therefore, ECL is playing an increasingly important role in the field of single-cell analysis. In ECL single-cell analysis, it is important to construct a suitable nanostructure interface to realize signal conversion. This review first briefly introduced the ECL system commonly used in single-cell analysis, then focused on the recent developments in ECL single-cell analysis on nanostructure interface, finally discussed the future challenges and outlooks of ECL single-cell analysis.

Automated summary

The development of single-cell analysis methods is important for research on cellular mechanisms, clinical diagnosis, and treatment. Electrochemiluminescence (ECL) technology, with its controllability in time and space and avoidance of interference from scattered light and impurities, plays an increasingly important role in single-cell analysis, particularly in the construction of suitable nanostructure interfaces for signal conversion.