期刊
ELECTROANALYSIS
卷 33, 期 7, 页码 1810-1818出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.202100117
关键词
Au; In2O3 nanocubes; label-free aptasensor; rapid detection; cardiac troponin I; high sensitivity
资金
- National Natural Science Foundation of China [22078148, 21727818]
- Medical Science and Technology Development Foundation, Nanjing Department of Health [YKK18071, ZKX17014]
- Joint research projects of Sino foreign cooperative education platform in Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
A novel label-free aptasensor was constructed for ultrasensitive and rapid detection of cTnI, with a low detection limit and wide linear range. Compared to existing analyzers, this aptasensor offers faster detection speed and excellent selectivity.
Cardiac Troponin I (cTnI) is a preferred biomarker to diagnose acute myocardial infarction which is one of the leading risks to health globally due to its short term. However, clinical analyzers are difficult to achieve its on-site quantitative detection. A novel label-free aptasensor was constructed to realize ultrasensitive and rapid recognition of cTnI. A nanocubic AuNPs/In2O3 composite was designed to provide synergistic effects of abundant active sites and signal magnification for aptamers grafting. Relying on a conductance-dependence strategy, this aptasensor can achieve the quantitative detection within 10 min, which is much faster than state-of-the-art analyzers, as well as exhibiting an ultrawide linear range of 0.1-1000 ng/mL and a low detection limit of 0.06 ng/mL with an excellent selectivity in the analysis of human serum.
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