4.7 Article

Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells

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MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells

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Summary: The study demonstrated that MCLR induced an increase in Ca2+ concentration in TM4 cells, leading to activation of apoptotic pathways. The use of the Ca2+ chelator Bapta-AM partially reversed MCLR-induced apoptosis, confirming the involvement of calcium homeostasis disruption. Additionally, MCLR activated the ER apoptotic pathway by activating caspase-12.

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