期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 220, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2021.112386
关键词
Atrazine; Long-term exposure; Immune system function; Apoptosis; Rat
资金
- Jilin Provincial Development andReform Commission Project [2019C0505]
- Science and Technology Project of the Department of Education, Jilin Province [JJKH20190103KJ]
- Science and Technology Project of the Department of Finance, Jilin Province (2018)
Long-term exposure to Atrazine (ATR) in rats resulted in increased spleen index, decreased white blood cells, significant reduction in Th1, Th2, and Th17 cells while an increase in Treg cells, changes in cytokine levels, and degenerative changes in the spleen. This suggests that long-term ATR exposure may inhibit immune system function in rats.
Atrazine (ATR) is a herbicide used widely worldwide. Because of its prolonged persistence in the environment and accumulation in the body, ATR exposure is a potential threat to human health. Our previous study showed that subacute exposure to ATR suppresses cellular immune function in mice. In this study, the effects of long-term exposure to ATR on rat immunological system function were measured. Four-week-old female Sprague-Dawley (SD) rats were treated with 0.4 mu mol/L, 2 mu mol/L and 10 mu mol/L ATR for 24 weeks. The results showed that the spleen index increased, white blood cells decreased, and monocytes and eosinophils increased. No obvious changes were detected in the numbers of neutrophils and lymphocytes. Th1, Th2, and Th17 cells decreased significantly, while Treg cells increased after long-term ATR exposure. Moreover, serum levels of cytokines, including TNF-alpha, INF-gamma, IL-6, and IL-12, decreased, while IL-1, IL-4, and IL-5 increased. Degenerative changes and cell apoptosis were found in the spleen; Caspase-3 and Caspase-9 were upregulated, and Bcl-2 was downregulated. These results suggested that long-term ATR exposure may inhibit immune system function.
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