4.6 Review

Cefiderocol: A Review in Serious Gram-Negative Bacterial Infections

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Cefiderocol as Rescue Therapy for Acinetobacter baumannii and Other Carbapenem-resistant Gram-negative Infections in Intensive Care Unit Patients

Marco Falcone et al.

Summary: In this study, cefiderocol was used to treat patients with bacteremia or ventilator-associated pneumonia caused by drug-resistant strains, showing a 70% clinical success rate and 90% survival rate. However, two patients experienced microbiological failure, highlighting the need for future prospective studies to further evaluate the effectiveness of the treatment.

CLINICAL INFECTIOUS DISEASES (2021)

Article Microbiology

Comparison of Agar Dilution to Broth Microdilution for Testing In Vitro Activity of Cefiderocol against Gram-Negative Bacilli

Mariana Albano et al.

Summary: The study found that the standard agar dilution method (AD) for determining CFDC MICs is unreliable for carbapenem-resistant bacteria, showing significant discordance compared to iron-depleted broth microdilution (ID-BMD). When testing different types of organisms, AD showed lower accuracy and consistency compared to ID-BMD.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

Article Microbiology

Cefiderocol Antimicrobial Susceptibility Testing against Multidrug-Resistant Gram-Negative Bacilli: a Comparison to Disk Diffusion to Broth Microdilution

C. Paul Morris et al.

Summary: Interpretation of cefiderocol ASTs varies significantly depending on the breakpoints used by CLSI, FDA, and EUCAST. DD offers a convenient alternative approach to BMD methods for cefiderocol AST, except for isolates of Acinetobacter baumannii complex.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

Article Infectious Diseases

Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial

Matteo Bassetti et al.

Summary: The study assessed the efficacy and safety of cefiderocol versus best available therapy in the treatment of patients with carbapenem-resistant Gram-negative infections. Cefiderocol showed similar clinical and microbiological efficacy to best available therapy in this heterogeneous patient population with infections caused by carbapenem-resistant Gram-negative bacteria, suggesting it as an option for the treatment of carbapenem-resistant infections in patients with limited treatment options.

LANCET INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial

Richard G. Wunderink et al.

Summary: Cefiderocol was found to be non-inferior to high-dose, extended-infusion meropenem in terms of all-cause mortality on day 14 in patients with Gram-negative nosocomial pneumonia, with similar tolerability. This suggests that cefiderocol is a potential option for the treatment of patients with nosocomial pneumonia, including those caused by multidrug-resistant Gram-negative bacteria.

LANCET INFECTIOUS DISEASES (2021)

Article Microbiology

Population Pharmacokinetic and Pharmacokinetic/ Pharmacodynamic Analyses of Cefiderocol, a Parenteral Siderophore Cephalosporin, in Patients with Pneumonia, Bloodstream Infection/Sepsis, or Complicated Urinary Tract Infection

Nao Kawaguchi et al.

Summary: Cefiderocol is a novel siderophore cephalosporin with antibacterial activity against Gram-negative bacteria, and a population pharmacokinetic model study showed that adequate plasma exposure can be achieved at the recommended dosing regimen for infected patients.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

Review Medicine, General & Internal

Epidemiology, Treatment, and Prevention of Nosocomial Bacterial Pneumonia

Shio-Shin Jean et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Infectious Diseases

In vitro activity of cefiderocol against aerobic Gram-negative bacterial pathogens from Germany

Michael Kresken et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Microbiology

In Vitro Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria

Shazad Mushtaq et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Article Microbiology

The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program

Daniel J. Diekema et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

Article Pharmacology & Pharmacy

New Drugs for Multidrug-Resistant Gram-Negative Organisms: Time for Stewardship

Shio-Shin Jean et al.

Article Infectious Diseases

Intrapulmonary pharmacokinetics of cefiderocol, a novel siderophore cephalosporin, in healthy adult subjects

Takayuki Katsube et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

Article Immunology

Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin

Takafumi Sato et al.

CLINICAL INFECTIOUS DISEASES (2019)

Article Immunology

Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections

Yohei Doi

CLINICAL INFECTIOUS DISEASES (2019)

Article Pharmacology & Pharmacy

Drug-drug interaction of cefiderocol, a siderophore cephalosporin, via human drug transporters

Takayuki Katsube et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2018)

Article Infectious Diseases

Pharmacodynamics of cefiderocol, a novel siderophore cephalosporin, in a Pseudomonas aeruginosa neutropenic murine thigh model

Islam M. Ghazi et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2018)

Article Infectious Diseases

Activity of the novel siderophore cephalosporin cefiderocol against multidrug-resistant Gram-negative pathogens

J. Dobias et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2017)

Article Microbiology

Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases

Tsukasa Ito-Horiyama et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Review Microbiology

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

Joanna S. Brooke

CLINICAL MICROBIOLOGY REVIEWS (2012)