☆ 4.4 Article

Metonitazene in the United States-Forensic toxicology assessment of a potent new synthetic opioid using liquid chromatography mass spectrometry

DRUG TESTING AND ANALYSIS (2021)

Brorphine-Investigation and quantitation of a new potent synthetic opioid in forensic toxicology casework using liquid chromatography-mass spectrometry

Alex J. Krotulski et al.

Summary: New synthetic opioids are constantly appearing in illicit drug markets as novel psychoactive substances. The Drug Enforcement Administration's effort to regulate isotonitazene led to the emergence of brorphine, a potent new NPS opioid. Analytical methods have been developed to identify and quantify brorphine in biological specimens, and its prevalence in forensic cases continues to rise in the United States.

JOURNAL OF FORENSIC SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of Nitazene 2-Benzylbenzimidazole Synthetic Opioids

Marthe M. Vandeputte et al.

Summary: Several 2-benzylbenzimidazole opioids, known as nitazenes, have emerged on the illicit market, with isotonitazene being the most frequently encountered member. These compounds, structurally unrelated to fentanyl, have high potency and efficacy, with some analogues even surpassing fentanyl. The unexpected very high potency of the N-desethylisotonitazene metabolite, exceeding that of isotonitazene itself, suggests potential significant in vivo consequences.

ACS CHEMICAL NEUROSCIENCE (2021)

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Review Biochemistry & Molecular Biology

DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles

Istvan Ujvary et al.

Summary: Etonitazene and its derivatives, developed in the late 1950s by the Swiss pharmaceutical giant CIBA, are potent analgesics with morphine-like effects. Recently, unscheduled synthetic opioids have emerged on the illicit drug market, leading to fatalities. This class of compounds has inspired research and led to the emergence of new psychoactive substances, impacting chemical neuroscience.

ACS CHEMICAL NEUROSCIENCE (2021)

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Article Medicine, Legal

Sample Mining and Data Mining: Combined Real-Time and Retrospective Approaches for the Identification of Emerging Novel Psychoactive Substances

Alex J. Krotulski et al.

JOURNAL OF FORENSIC SCIENCES (2020)

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Article Chemistry, Analytical

Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework

Alex J. Krotulski et al.

JOURNAL OF ANALYTICAL TOXICOLOGY (2020)

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Metonitazene in the United States-Forensic toxicology assessment of a potent new synthetic opioid using liquid chromatography mass spectrometry

相关参考文献

Brorphine-Investigation and quantitation of a new potent synthetic opioid in forensic toxicology casework using liquid chromatography-mass spectrometry

Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of Nitazene 2-Benzylbenzimidazole Synthetic Opioids

DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles

Sample Mining and Data Mining: Combined Real-Time and Retrospective Approaches for the Identification of Emerging Novel Psychoactive Substances

Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework

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