In vitro metabolic studies of novel selective androgen receptor modulators and their use for doping control analysis

Selective androgen receptor modulators were developed as a treatment of choice for diseases that are currently treated or symtomatically treated with steroidal androgens. The present study aimed to explore the metabolic pathways of four structurally unrelated SARMs, namely, PF-06260414, TFM-4AS-1, BMS-564929, and GSK 2881078, in terms of their potential toxicology or doping control analysis. Detected metabolism, mainly resulting from a single or multiple hydroxylations, methoxylation, demethylation, dehydrogenation, and glucuronidation, was considered as potential markers of intake of examined SARMs.

Automated summary

This study aimed to explore the metabolic pathways of four structurally unrelated SARMs and detect potential markers of intake of these substances through the analysis of their metabolites.