4.7 Review

Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy

Yike Yang et al.

Summary: This study found that while MitoQ administration in late gestation could protect mice from hypertension and kidney damage induced by RUPP, it exacerbated the PE phenotype when given in early gestation, indicating the necessity of mild oxidative stress for trophoblast proliferation, invasion, and migration.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Review Peripheral Vascular Disease

The Role of Mitochondrial Dysfunction in Preeclampsia: Causative Factor or Collateral Damage?

Alex N. Smith et al.

Summary: Preeclampsia, a new onset hypertension in pregnancy, affects 5%-10% of the world's population and is a leading cause of morbidity and mortality for both the mother and fetus. Recent studies suggest that mitochondrial dysfunction may contribute to the pathophysiology of preeclampsia, highlighting a potential avenue for therapeutic intervention.

AMERICAN JOURNAL OF HYPERTENSION (2021)

Article Biochemistry & Molecular Biology

PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation

Takashi Shimizu et al.

Summary: The study revealed that PERK plays a role in PAH pathophysiology in BMPR2 heterozygous mice by regulating the UPR pathway. PERK inhibition resulted in reduced PDGFRD-STAT1 signaling and glycolysis in hypoxic BMPR2 heterozygous PASMCs, ultimately ameliorating pulmonary vascular remodeling in a PAH model. These findings suggest that PERK inhibition could be a promising therapeutic strategy for patients with PAH, regardless of BMPR2 mutation status.

SCIENCE SIGNALING (2021)

Review Biochemistry & Molecular Biology

Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications

Xiang-Qun Hu et al.

Summary: Hypoxia during gestation has significant impacts on maternal complications and fetal development. Mitochondrial ROS play a key role in placental dysfunction and pregnancy complications. Therapeutic approaches targeting mitochondrial ROS in placental cells are discussed for potential treatment strategies.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension

Maki Niihori et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Article Genetics & Heredity

Multiple mitochondrial dysfunctions syndrome 1: An unusual cause of developmental pulmonary hypertension

Alona Birjiniuk et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2020)

Article Cardiac & Cardiovascular Systems

PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats

Joshua R. Sheak et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Review Cell Biology

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Pearl Lee et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction

K. J. Botting et al.

SCIENCE ADVANCES (2020)

Review Multidisciplinary Sciences

The integrated stress response: From mechanism to disease

Mauro Costa-Mattioli et al.

SCIENCE (2020)

Review Cardiac & Cardiovascular Systems

Endoplasmic reticulum stress and pulmonary hypertension

Yanan Hu et al.

PULMONARY CIRCULATION (2020)

Article Cardiac & Cardiovascular Systems

Preeclampsia Pathophysiology, Challenges, and Perspectives

Sarosh Rana et al.

CIRCULATION RESEARCH (2019)

Article Biochemistry & Molecular Biology

Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1 In Vitro and In Vivo

Chin-Chang Cheng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

Influence of 2-Methoxyestradiol and Sex on Hypoxia-Induced Pulmonary Hypertension and Hypoxia-Inducible Factor-1-α

Craig K. Docherty et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

Article Cardiac & Cardiovascular Systems

Medical Therapy for Heart Failure Associated With Pulmonary Hypertension

Jason G. E. Zelt et al.

CIRCULATION RESEARCH (2019)

Review Biochemistry & Molecular Biology

mRNA-to-protein translation in hypoxia

Nancy T. Chee et al.

MOLECULAR CANCER (2019)

Article Biochemistry & Molecular Biology

H2S attenuates endoplasmic reticulum stress in hypoxia-induced pulmonary artery hypertension

Jianjun Wu et al.

BIOSCIENCE REPORTS (2019)

Article Hematology

Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension Novel Effects of an Old Drug

Mohammad Abdul Hai Siddique et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Article Respiratory System

Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension

Cheng-Jun Hu et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Multidisciplinary Sciences

Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia

Hong Wa Yung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Increased BMI has a linear association with late-onset preeclampsia: A population-based study

Pierre-Yves Robillard et al.

PLOS ONE (2019)

Article Multidisciplinary Sciences

CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

Yongting Luo et al.

NATURE COMMUNICATIONS (2019)

Article Respiratory System

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

Gerald Simonneau et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Biochemistry & Molecular Biology

Protein Misfolding during Pregnancy: New Approaches to Preeclampsia Diagnostics

Elizaveta M. Gerasimova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cell Biology

Signaling and Regulation of the Mitochondrial Unfolded Protein Response

Nandhitha Uma Naresh et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

Article Physiology

Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in reduced uterine perfusion pressure rats

Venkata Ramana Vaka et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2019)

Review Endocrinology & Metabolism

Trophoblast lineage specification, differentiation and their regulation by oxygen tension

Ching-Wen Chang et al.

JOURNAL OF ENDOCRINOLOGY (2018)

Article Physiology

PLCγ1-PKCε-IP3R1 signaling plays an important role in hypoxia-induced calcium response in pulmonary artery smooth muscle cells

Vishal R. Yadav et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Article Physiology

Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

Karthik Suresh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Article Critical Care Medicine

Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2 alpha Inhibitor

Zhiyu Dai et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension A Population-Based Cohort Study in Ontario, Canada

D. Thiwanka Wijeratne et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2018)

Review Biochemistry & Molecular Biology

The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia

Berthold Huppertz

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2018)

Review Pharmacology & Pharmacy

The integrated stress response system in cardiovascular disease

Diana Santos-Ribeiro et al.

DRUG DISCOVERY TODAY (2018)

Article Respiratory System

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension

Oleg Pak et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Review Biochemistry & Molecular Biology

Oxidative Stress in Preeclampsia and Placental Diseases

Rajaa Aouache et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Physiology

GESTATIONAL HYPOXIA AND DEVELOPMENTAL PLASTICITY

Charles A. Ducsay et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Cell Biology

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

Ronald C. Wek

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension A Population-Based Cohort Study in Ontario, Canada

D. Thiwanka Wijeratne et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2018)

Article Physiology

Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia

Lissette C. Sanchez-Aranguren et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Obstetrics & Gynecology

Risk of abnormal fetal growth in women with early- and late-onset preeclampsia

Tai-Ho Hung et al.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2018)

Review Cell Biology

Human trophoblast invasion: new and unexpected routes and functions

Gerit Moser et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Topotecan prevents hypoxia-induced pulmonary arterial hypertension and inhibits hypoxia-inducible factor-1α and TRPC channels

Yongliang Jiang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Biophysics

Long-Term Health Outcomes in High-Altitude Pulmonary Hypertension

Jeffrey C. Robinson et al.

HIGH ALTITUDE MEDICINE & BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Hypoxia-induced activation of specific members of the NF-kB family and its relevance to pulmonary vascular remodeling

Hardik Patel et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)

Article Obstetrics & Gynecology

Placental respiratory chain complex activities in high risk pregnancies

Mojtaba Beyramzadeh et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2017)

Editorial Material Multidisciplinary Sciences

Mediating ER-mitochondrial cross-talk

Alyssa A. Lombardi et al.

SCIENCE (2017)

Article Medicine, Research & Experimental

MitoKATP regulating HIF/miR210/ISCU signaling axis and formation of a positive feedback loop in chronic hypoxia-induced PAH rat model

Yang Lu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

Article Multidisciplinary Sciences

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Tom J. Phillips et al.

SCIENTIFIC REPORTS (2017)

Article Physiology

Chronic hypoxia alters maternal uterine and fetal hemodynamics in the full-term pregnant guinea pig

Sifa Turan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2017)

Review Biochemistry & Molecular Biology

Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension

David J. R. Fulton et al.

ANTIOXIDANTS (2017)

Article Physiology

Hydrogen peroxide is a critical regulator of the hypoxia-induced alterations of store-operated Ca2+ entry into rat pulmonary arterial smooth muscle cells

Tao-Xiang Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

Article Physiology

Maternal vascular responses to hypoxia in a rat model of intrauterine growth restriction

Mais M. Aljunaidy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2016)

Review Biochemistry & Molecular Biology

The integrated stress response

Karolina Pakos-Zebrucka et al.

EMBO REPORTS (2016)

Article Biophysics

Chronic Normobaric Hypoxia Induces Pulmonary Hypertension in Rats: Role of NF-κB

Junming Fan et al.

HIGH ALTITUDE MEDICINE & BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

Dun-Xian Tan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

David M. Booth et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease

Mariko Horii et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Cardiac & Cardiovascular Systems

miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation

Tianji Chen et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Critical Care Medicine

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension

Chiara Federici et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Review Pathology

The Role of Endoplasmic Reticulum Stress in Human Pathology

Scott A. Oakes et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 10 (2015)

Article Hematology

Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia

Maria Haslip et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Review Cell Biology

Calcium signaling and cell proliferation

Mauro Cunha Xavier Pinto et al.

CELLULAR SIGNALLING (2015)

Article Cardiac & Cardiovascular Systems

Pathophysiology and Treatment of High-Altitude Pulmonary Vascular Disease

Martin R. Wilkins et al.

CIRCULATION (2015)

Review Biochemistry & Molecular Biology

Mitochondria-targeted antioxidants

Anne O. Oyewole et al.

FASEB JOURNAL (2015)

Article Biochemistry & Molecular Biology

Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension

Sherry E. Adesina et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Developmental Biology

Endoplasmic reticulum stress is induced in the human placenta during labour

J. H. W. Veerbeek et al.

PLACENTA (2015)

Article Genetics & Heredity

Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency

Uwe Ahting et al.

FRONTIERS IN GENETICS (2015)

Review Cell Biology

Hypoxia signaling pathways: modulators of oxygen-related organelles

Miriam J. Schonenberger et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension

Masayuki Koyama et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)

Article Critical Care Medicine

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

Molly K. Ball et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Review Biochemistry & Molecular Biology

The Integrated Stress Response in Lung Disease

Emily F. A. van 't Wout et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Review Biochemistry & Molecular Biology

The Scanning Mechanism of Eukaryotic Translation Initiation

Alan G. Hinnebusch

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)

Article Biochemistry & Molecular Biology

An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells

Andrew Hale et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Baicalin Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via the AKT/HIF-1α/p27-Associated Pathway

Lin Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Biochemistry & Molecular Biology

Deregulation of Pancreas-Specific Oxidoreductin ERO1β in the Pathogenesis of Diabetes Mellitus

Motoharu Awazawa et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Xi Chen et al.

NATURE (2014)

Article Obstetrics & Gynecology

Maternal Morbidity Associated With Early-Onset and Late-Onset Preeclampsia

Sarka Lisonkova et al.

OBSTETRICS AND GYNECOLOGY (2014)

Article Developmental Biology

Optimising sample collection for placental research

G. J. Burton et al.

PLACENTA (2014)

Article Pharmacology & Pharmacy

Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight

Takashige Kawakami et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Article Pathology

miR-210 Inhibits Trophoblast Invasion and Is a Serum Biomarker for Preedampsia

Lauren Anton et al.

AMERICAN JOURNAL OF PATHOLOGY (2013)

Article Biochemistry & Molecular Biology

Mitochondrial Hyperpolarization in Pulmonary Vascular Remodeling Mitochondrial Uncoupling Protein Deficiency as Disease Model

Oleg Pak et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Differential Regulation of Pulmonary Vascular Cell Growth by Hypoxia-Inducible Transcription Factor-1α and Hypoxia-Inducible Transcription Factor-2α

Aftab Ahmad et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Pathology

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

Gregg L. Semenza

Annual Review of Pathology-Mechanisms of Disease (2013)

Article Cardiac & Cardiovascular Systems

Attenuating Endoplasmic Reticulum Stress as a Novel Therapeutic Strategy in Pulmonary Hypertension

Peter Dromparis et al.

CIRCULATION (2013)

Article Respiratory System

Pulmonary Hypertension due to Lung Disease and/or Hypoxia

Steven D. Nathan et al.

CLINICS IN CHEST MEDICINE (2013)

Review Biochemistry & Molecular Biology

Redox regulation of protein kinases

Aoife Corcoran et al.

FEBS JOURNAL (2013)

Article Biochemistry & Molecular Biology

Erythrocytosis and Pulmonary Hypertension in a Mouse Model of Human HIF2A Gain of Function Mutation

Qiulin Tan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Obstetrics & Gynecology

The severity of hypoxic changes and oxidative DNA damage in the placenta of early-onset preeclamptic women and fetal growth restriction

Chiharu Kimura et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2013)

Review Biochemistry & Molecular Biology

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

Ryan J. Mailloux et al.

TRENDS IN BIOCHEMICAL SCIENCES (2013)

Article Physiology

Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension

Xiao-Ru Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)

Article Physiology

miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia

Deming Gou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM)

Tiziana Anelli et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Review Reproductive Biology

The Role of Hypoxia and Hypoxia-Inducible Factor-1Alpha in Preeclampsia Pathogenesis

Reshef Tal

BIOLOGY OF REPRODUCTION (2012)

Article Hematology

Hypoxia-inducible factors and their roles in energy metabolism

Nobuhito Goda et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2012)

Article Neurosciences

Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats

H. G. Richter et al.

JOURNAL OF PHYSIOLOGY-LONDON (2012)

Article Multidisciplinary Sciences

An oxygen-regulated switch in the protein synthesis machinery

James Uniacke et al.

NATURE (2012)

Article Developmental Biology

MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

S. Muralimanoharan et al.

PLACENTA (2012)

Article Multidisciplinary Sciences

Digoxin inhibits development of hypoxic pulmonary hypertension in mice

Edsel M. Abud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Pharmacology & Pharmacy

Cadmium-induced teratogenicity: Association with ROS-mediated endoplasmic reticulum stress in placenta

Zhen Wang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Activation of the Unfolded Protein Response is Associated with Pulmonary Hypertension

Michael E. Yeager et al.

Pulmonary Circulation (2012)

Article Pharmacology & Pharmacy

YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice

Jin Won Huh et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2011)

Article Cell Biology

The Role of Nogo and the Mitochondria-Endoplasmic Reticulum Unit in Pulmonary Hypertension

Gopinath Sutendra et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Review Obstetrics & Gynecology

Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia

Graham J. Burton et al.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2011)

Article Biochemistry & Molecular Biology

Effects of Mitochondrial Potassium Channel and Membrane Potential on Hypoxic Human Pulmonary Artery Smooth Muscle Cells

Hong-ling Hu et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

Article Cell Biology

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

Robin A. J. Smith et al.

MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE (2010)

Review Biochemistry & Molecular Biology

Molecular Mechanisms Regulating Oxidative Activity of the Ero1 Family in the Endoplasmic Reticulum

Timothy J. Tavender et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Article Biochemistry & Molecular Biology

Prolonged Hypoxia Increases ROS Signaling and RhoA Activation in Pulmonary Artery Smooth Muscle and Endothelial Cells

Annie Y. Chi et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Article Medicine, Research & Experimental

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

Michele M. Hickey et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

Ru-Feng Wu et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Review Physiology

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

Kurt R. Stenmark et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Review Biochemistry & Molecular Biology

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

Yuichiro Shimizu et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Review Biochemistry & Molecular Biology

How mitochondria produce reactive oxygen species

Michael P. Murphy

BIOCHEMICAL JOURNAL (2009)

Review Biochemistry & Molecular Biology

Mitochondria and reactive oxygen species

Alicia J. Kowaltowski et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Biochemistry & Molecular Biology

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

Liping Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Pathology

Oxidative stress, gene expression, and protein changes induced in the human placenta during labor

Tereza Cindrova-Davies et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

Article Biochemistry & Molecular Biology

NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

Lena Serrander et al.

BIOCHEMICAL JOURNAL (2007)

Article Developmental Biology

Chronic hypoxia in vivo reduces placental oxidative stress

S. Zamudio et al.

PLACENTA (2007)

Article Multidisciplinary Sciences

The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

Sebastien Bonnet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

High-altitude hypoxia and preeclampsia

Stacy Zamudio

FRONTIERS IN BIOSCIENCE-LANDMARK (2007)

Article Cell Biology

Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport

Michael Trenker et al.

NATURE CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes

Qing-Song Wang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Article Cardiac & Cardiovascular Systems

Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling

David L. Hoffman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Cell Biology

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

Gyorgy Szabadkai et al.

JOURNAL OF CELL BIOLOGY (2006)

Article Physiology

Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1

Ori Nevo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)

Review Cardiac & Cardiovascular Systems

Hypoxia-induced pulmonary vascular remodeling - Cellular and molecular mechanisms

Kurt R. Stenmark et al.

CIRCULATION RESEARCH (2006)

Article Critical Care Medicine

Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy

Nathalie Koulmann et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Review Obstetrics & Gynecology

The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy

JL James et al.

HUMAN REPRODUCTION UPDATE (2006)

Review Developmental Biology

The uterine spiral arteries in human pregnancy: Facts and controversies

R. Pijnenborg et al.

PLACENTA (2006)

Article Biochemistry & Molecular Biology

PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

SB Cullinan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Neurosciences

Mitochondrial formation of reactive oxygen species

JF Turrens

JOURNAL OF PHYSIOLOGY-LONDON (2003)

Article Biochemistry & Molecular Biology

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

SB Cullinan et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Obstetrics & Gynecology

Uterine blood flow -: A determinant of fetal growth

U Lang et al.

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2003)

Article Developmental Biology

Remodelling of uteroplacental arteries is decreased in high altitude placentae

MT van Patot et al.

PLACENTA (2003)

Article Biochemistry & Molecular Biology

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

HP Harding et al.

MOLECULAR CELL (2003)

Article Physiology

Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation

M Sweeney et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2002)

Article Physiology

Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

LA Shimoda et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

Article Cardiac & Cardiovascular Systems

Ca2+-activated K+ channels modulate basal and E2β-induced rises in uterine blood flow in ovine pregnancy

CR Rosenfeld et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)

Article Medicine, Research & Experimental

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

I Caniggia et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)