Advancing lung organoids for COVID-19 research

The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.

Automated summary

The COVID-19 pandemic highlighted the necessity of developing effective treatments against emerging viruses. Collaborations between cell biologists and virologists have rapidly advanced representative organoid model systems, particularly lung organoids, for studying SARS-CoV-2 and future pandemic viruses, paving the way for effective treatments.