4.5 Article

Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Mifepristone (RU486) inhibits dietary lipid digestion by antagonizing the role of glucocorticoid receptor on lipase transcription

Peng Ma et al.

Summary: The drug RU486 can prevent lipid digestion and absorption in both flies and mice, possibly through its antagonist effect on the glucocorticoid receptor. It was also found to influence the transcription of pancreatic lipase and regulate lipid metabolism. Additionally, RU486 administration inhibited high fat diet-induced obesity in both mice and flies.

ISCIENCE (2021)

Article Multidisciplinary Sciences

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

Ikuo Kimura et al.

SCIENCE (2020)

Article Biology

Early-life hypoxia alters adult physiology and reduces stress resistance and lifespan in Drosophila

Danielle M. Polan et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila

Toshitaka Yamauchi et al.

ISCIENCE (2020)

Article Medicine, Research & Experimental

Intestinal alkaline phosphatase targets the gut barrier to prevent aging

Florian Kuehn et al.

JCI INSIGHT (2020)

Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Immunology

The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila

Saeideh Davoodi et al.

JOURNAL OF IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

Article Geriatrics & Gerontology

Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system

Maricela Robles-Murguia et al.

NPJ AGING AND MECHANISMS OF DISEASE (2019)

Review Geriatrics & Gerontology

Developmental Origins of Health Span and Life Span: A Mini-Review

Joshua D. Preston et al.

GERONTOLOGY (2018)

Article Medicine, General & Internal

Origins of lifetime health around the time of conception: causes and consequences

Tom P. Fleming et al.

LANCET (2018)

Article Multidisciplinary Sciences

Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila

Fumiaki Obata et al.

NATURE COMMUNICATIONS (2018)

Article Geriatrics & Gerontology

Mifepristone Reduces Food Palatability and Affects Drosophila Feeding and Lifespan

Ryuichi Yamada et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2017)

Article Multidisciplinary Sciences

Developmental diet regulates Drosophila lifespan via lipid autotoxins

M. Irina Stefana et al.

NATURE COMMUNICATIONS (2017)

Review Multidisciplinary Sciences

How colonization by microbiota in early life shapes the immune system

Thomas Gensollen et al.

SCIENCE (2016)

Article Cell Biology

A Drosophila model to investigate the neurotoxic side effects of radiation exposure

Lisa J. Sudmeier et al.

DISEASE MODELS & MECHANISMS (2015)

Article Multidisciplinary Sciences

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

Yael R. Nobel et al.

NATURE COMMUNICATIONS (2015)

Article Endocrinology & Metabolism

OPINION Antibiotics in early life and obesity

Laura M. Cox et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Article Biochemistry & Molecular Biology

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

Haiyang Chen et al.

Article Geriatrics & Gerontology

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Claudio Franceschi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

Article Multidisciplinary Sciences

Drosophila Microbiota Modulates Host Metabolic Gene Expression via IMD/NF-κB Signaling

Berra Erkosar Combe et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

MEF2 Is an In Vivo Immune-Metabolic Switch

Rebecca I. Clark et al.

Article Biochemistry & Molecular Biology

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

Edward Owusu-Ansah et al.

Article Biochemistry & Molecular Biology

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

Shannon L. Russell et al.

EMBO REPORTS (2012)

Article Gastroenterology & Hepatology

Antibiotic use and inflammatory bowel diseases in childhood

Anders Hviid et al.

Article Multidisciplinary Sciences

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

Takayuki Kuraishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biotechnology & Applied Microbiology

Identification and quantification of acetic acid bacteria in wine and vinegar by TaqMan-MGB probes

M. J. Torija et al.

FOOD MICROBIOLOGY (2010)

Article Multidisciplinary Sciences

Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification

Eric L. Campbell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Gastroenterology & Hepatology

Role of alkaline phosphatase in colitis in man and rats

A. Tuin et al.

Article Cell Biology

The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner

Herve Tricoire et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2009)

Article Multidisciplinary Sciences

The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

Justin R. DiAngelo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Immunology

Specific memory within innate immune systems

J Kurtz

TRENDS IN IMMUNOLOGY (2005)

Review Multidisciplinary Sciences

Inflammatory exposure and historical changes in human life-spans

CE Finch et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

A conditional tissue-specific transgene expression system using inducible GAL4

T Osterwalder et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)