期刊
DIGESTIVE DISEASES AND SCIENCES
卷 67, 期 8, 页码 3518-3528出版社
SPRINGER
DOI: 10.1007/s10620-021-07225-6
关键词
Pharyngeal squamous cell carcinoma; Pharyngeal neoplasm; Pharyngeal carcinoma; Endoscopic dissection; Endoscopic submucosal resection; Endoscopic resection
This meta-analysis of 10 studies from Asian countries indicated that ESD is an effective and safe option for the management of superficial pharyngeal cancers, with high rates of en bloc and complete resection. However, most analyses were limited by significant heterogeneity. Meta-regression analysis suggested that heterogeneity was influenced by tumor size and histology, while no evidence of publication bias was found through funnel plots and Egger's test. Further studies, particularly from Western countries, are needed to validate these findings.
Background and Aims Studies evaluating the role of endoscopic submucosal dissection (ESD) in the management of superficial pharyngeal cancers have reported promising results. This meta-analysis evaluates the efficacy and safety of ESD in the management of superficial pharyngeal cancers. Methods We reviewed several databases from inception to September 03, 2020, to identify studies evaluating the efficacy and safety of ESD in the management of superficial pharyngeal cancers. Our outcomes of interest were en bloc resection rate, complete resection rate, adverse events, and rates of local recurrence. Pooled rates with 95% confidence intervals (CI) for all outcomes were calculated using random-effect model. Heterogeneity was assessed by I-2 statistic. We assessed publication bias by using funnel plots and Egger's test. We conducted meta-regression analysis to explore heterogeneity in analyses. Results Ten studies were included in analyses. All studies were from Asia. Pooled rates (95% CI) for en bloc resection and complete resection were 94% (87%, 97%) and 72% (62%, 80%), respectively. The pooled rates (95% CI) for adverse events and local recurrence were 10% (5%, 17%) and 1.9% (0.9%, 4%), respectively. Most of the analyses were limited by substantial heterogeneity. On meta-regression analysis, the heterogeneity was explained by size of tumor and histology. Funnel plots and Egger's test showed no evidence of publication bias. Conclusions This meta-analysis including studies from Asian countries demonstrated that ESD is an efficacious and safe option in the management of superficial pharyngeal cancers. More studies and studies from Western countries are needed to further validate these findings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据