期刊
DIGESTIVE DISEASES
卷 40, 期 3, 页码 345-354出版社
KARGER
DOI: 10.1159/000517736
关键词
Human microbiome; Esophageal diseases; Esophageal neoplasms; Gastrointestinal microbiome; Barrett's esophagus
资金
- T32 training grant [5T32HD060554-10]
- Thrasher Research Fund
- Vanderbilt Institute for Clinical and Translational Research
- NIAID [R21AI154016-01, R21AI149262, R21AI14232, R21AI142321-01A1S1, U19AI095227, P30AI110527]
- NHLBI [1R01HL146401]
- Vanderbilt University Medical Center
- American College of Gastroenterology Junior Faculty Development Award
- Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health [K12HD087023]
Further research is necessary to uncover the mechanisms by which the oral microbiome impacts the development and progression of esophageal diseases, as well as to explore if changes in the oral microbiome can influence the natural course of different esophageal conditions.
Background: Esophageal conditions result in significant morbidity and mortality worldwide. There is growing enthusiasm for discerning the role of microbiome in esophageal diseases. Conceivably, the focus has been on examining the role of local microbiome in esophageal diseases although this is somewhat limited by the invasive approach required to sample the esophageal tissue. Given the ease of sampling the oral cavity combined with the advances in genomic techniques, there is immense interest in discovering the role of the oral microbiome in esophageal conditions. Summary: In this review, we aim to discuss the current evidence highlighting the association between the oral microbiome and esophageal diseases. In particular, we have focused on summarizing the alterations in oral microbiome associated with malignant, premalignant, and benign esophageal cancers, inflammatory and infectious conditions, and esophageal dysmotility diseases. Identifying alterations in the oral microbiome is a key to advancing our understanding of the etiopathogenesis and progression of esophageal diseases, promoting novel diagnostics, and laying the foundation for personalized treatment approaches. Key Messages: Further studies are needed to unravel the mechanisms by which the oral microbiome influences the development and progression of esophageal diseases, as well as to investigate whether alterations in the oral microbiome can impact the natural history of various esophageal diseases.
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